Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
In: Bioorganic & medicinal chemistry letters (Print), Jg. 20 (2010), Heft 9, S. 2950-2953
academicJournal
- print, 21 ref
Zugriff:
In silico analysis of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate (2) predicts that this molecule should be successfully docked in the PAS, and easily accommodated in the CAS of AChE. The synthesis and the AChE/BuChE inhibition studies are reported, confirming that compound 2 is a potent and selective AChE inhibitor, and consequently, a new lead compound for further development into new dual CAS/PAS cholinergic agents for the treatment of Alzheimer's disease.
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Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
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Autor/in / Beteiligte Person: | SORIANO, Elena ; SAMADI, Abdelouahid ; CHIOUA, Mourad ; DE LOS RIOS, Cristobal ; MARCO-CONTELLES, José |
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Zeitschrift: | Bioorganic & medicinal chemistry letters (Print), Jg. 20 (2010), Heft 9, S. 2950-2953 |
Veröffentlichung: | Amsterdam: Elsevier, 2010 |
Medientyp: | academicJournal |
Umfang: | print, 21 ref |
ISSN: | 0960-894X (print) |
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