Antifungal and Cytotoxic Activity of Withanolides from Acnistus arborescens
In: Journal of natural products (Print), Jg. 73 (2010), Heft 7, S. 1313-1317
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Zugriff:
Three compounds were isolated from Acnistus arborescens, a tree commonly used in South and Central America in traditional medicine against several infectious diseases, some of which are caused by fungi. Bioassay-guided fractionation of a MeOH extract of leaves, based on its anti-Pneumocystis carinii activity, led to the isolation of compounds 1-3. Mono- and bidimensional NMR analyses enabled identification of two new withanolides, (20R,22R)-5β,6β-epoxy-4β,12β,20-trihydroxy-1-oxowith-2-en-24-enolide (1) and (20R,22R)-16β-acetoxy-3β,4β;5β,6β-diepoxy-12β,20-dihydroxy-1-oxowith-24-enolide (2), and withanolide D (3). Antifungal activity on 13 fungi responsible for human infections (five dennatophytes, one nondermatophyte mold, six yeasts, and Pneumocystis carinii) was examined. Cytotoxicity of these compounds was also evaluated in vitro.
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Antifungal and Cytotoxic Activity of Withanolides from Acnistus arborescens
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| Autor/in / Beteiligte Person: | ROUMY, Vincent ; BIABIANY, Murielle ; BAILLEUL, François ; HENNEBELLE, Thierry ; ALIOUAT, Moukhtar ; POTTIER, Muriel ; JOSEPH, Henry ; JOHA, Sami ; QUESNEL, Bruno ; ALKHATIB, Racha ; SAHPAZ, Sevser |
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| Zeitschrift: | Journal of natural products (Print), Jg. 73 (2010), Heft 7, S. 1313-1317 |
| Veröffentlichung: | Northbrook, IL: American Society of Pharmacognosy, 2010 |
| Medientyp: | academicJournal |
| Umfang: | print, |
| ISSN: | 0163-3864 (print) |
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