FMRI correlates of apraxia in Parkinson's disease patients OFF medication
In: Experimental neurology (Print), Jg. 225 (2010), Heft 2, S. 416-422
academicJournal
- print, 3/4 p
Zugriff:
Impairment of hand dexterity in Parkinson's disease (PD) is usually attributed to bradykinesia. Recently, behavioral studies illustrated that decreased dexterity might also be due to limb-kinetic apraxia (LkA), as demonstrated by impaired performance in a coin rotation task. Here, we provide a first investigation on whether functional magnetic resonance imaging (FMRI) may reveal specific brain activation patterns for PD patients with impaired performance in a coin rotation task. We compared coin rotation as an apraxia task to simple finger tapping as a bradykinesia task in ten PD patients OFF medication and matched healthy controls. In addition to a tendency for general overactivation, PD patients showed a perirolandic dissociation with precentral overactivation and postcentral underactivation. This finding significantly separated PD patients from healthy controls.
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FMRI correlates of apraxia in Parkinson's disease patients OFF medication
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Autor/in / Beteiligte Person: | FOKI, T ; PIRKER, W ; PUSSWALD, G ; TRATTNIG, S ; AUFF, E ; BEISTEINER, R ; KLINGER, N ; GEISSLER, A ; RATH, J ; STEINKELLNER, T ; HOELLINGER, I ; GRUBER, S ; HAUBENBERGER, D ; LEHRNER, J |
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Zeitschrift: | Experimental neurology (Print), Jg. 225 (2010), Heft 2, S. 416-422 |
Veröffentlichung: | Amsterdam: Elsevier, 2010 |
Medientyp: | academicJournal |
Umfang: | print, 3/4 p |
ISSN: | 0014-4886 (print) |
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