Antimicrobial characterisation of solithromycin. (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci
In: International journal of antimicrobial agents (Print), Jg. 37 (2011), Heft 1, S. 39-45
academicJournal
- print, 25 ref
Zugriff:
Solithromycin (CEM-101) is a novel fluoroketolide with high potency against Gram-positive and Gram-negative bacteria commonly associated with community-acquired respiratory tract infections and skin and skin-structure infections. In this study, solithromycin and comparator antimicrobials were tested against a contemporary collection of Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, Enterococcus faecium and other Enterococcus spp. collected in the SENTRY Antimicrobial Surveillance Program. Solithromycin was active against S. aureus [minimum inhibitory concentration for 50% of the organisms (MIC50)=0.12μg/mL] and was two-fold more active than telithromycin (MIC50 =0.25 μg/mL). Solithromycin was more potent against meticillin (oxacillin)-susceptible S. aureus [MIC50=0.06 μg/mL and MIC for 90% of the organisms (MIC50)=0.12 μg/mL) compared with meticillin (oxacillin)-resistant S. aureus (MIC50= 0.12 μg/mL and MIC90 > 16 μg/mL). Solithromycin activity was reduced amongst heterogeneous vancomycin-intermediate S. aureus and vancomycin-resistant S. aureus (MIC50 > 16 μg/mL). Against strains with defined susceptibilities to erythromycin, clindamycin and telithromycin, solithromycin showed potent inhibition againstall combinations (MIC50= 0.06 μg/mL) except those with non-susceptibility to telithromycin (>2 μg/mL) (MIC50 > 16 μg/mL). The solithromycin MIC50 for E. faecium ( 1 μg/mL) was four-fold higher than the MIC50 for E. faecalis (0.25 μg/mL). In summary, solithromycin demonstrated high potency against many Staphylococcus and Enterococcus spp. isolated from contemporary infections worldwide.
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Antimicrobial characterisation of solithromycin. (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci
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Autor/in / Beteiligte Person: | PUTNAM, Shannon D ; SADER, Helio S ; FARRELL, David J ; BIEDENBACH, Douglas J ; CASTANHEIRA, Mariana |
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Zeitschrift: | International journal of antimicrobial agents (Print), Jg. 37 (2011), Heft 1, S. 39-45 |
Veröffentlichung: | Amsterdam: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 25 ref |
ISSN: | 0924-8579 (print) |
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