BRCA1- Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study
In: Journal of clinical oncology, Jg. 28 (2010), Heft 36, S. 5265-5273
Online
academicJournal
- print, 49 ref
Zugriff:
Purpose The Dutch MRI Screening Study on early detection of hereditary breast cancer started in 1999. We evaluated the long-term results including separate analyses of BRCA1 and BRCA2 mutation carriers and first results on survival. Patients and Methods Women with higher than 15% cumulative lifetime risk (CLTR) of breast cancer were screened with biannual clinical breast examination and annual mammography and magnetic resonance imaging (MRI). Participants were divided into subgroups: carriers of a gene mutation (50% to 85% CLTR) and two familial groups with high (30% to 50% CLTR) or moderate risk (15% to 30% CLTR). Results Our update contains 2,157 eligible women including 599 mutation carriers (median follow-up of 4.9 years from entry) with 97 primary breast cancers detected (median follow-up of 5.0 years from diagnosis). MRI sensitivity was superior to that of mammography for invasive cancer (77.4% v 35.5%; P < .00005), but not for ductal carcinoma in situ. Results in the BRCA1 group were worse compared to the BRCA2, the high-, and the moderate-risk groups, respectively, for mammography sensitivity (25.0% v 61.5%, 45.5%, 46.7%), tumor size at diagnosis ≤ 1 cm (21.4% v 61.5%, 40.9%, 63.6%), proportion of DCIS (6.5% v 18.8%, 14.8%, 31.3%) and interval cancers (32.3% v 6.3%, 3.7%, 6.3%), and age at diagnosis younger than 30 years (9.7% v 0%). Cumulative distant metastasis-free and overall survival at 6 years in all 42 BRCA1/2 mutation carriers with invasive breast cancer were 83.9% (95% CI, 64.1 % to 93.3%) and 92.7% (95% CI, 79.0% to 97.6%), respectively, and 100% in the familial groups (n = 43). Conclusion Screening results were somewhat worse in BRCA1 mutation carriers, but 6-year survival was high in all risk groups.
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BRCA1- Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study
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Autor/in / Beteiligte Person: | RIJNSBURGER, Adriana J ; OBDEIJN, Inge-Marie ; PETERSE, Hans ; TOLLENAAR, Rob A. E. M ; HOOGERBRUGGE, Nicoline ; MEIJER, Sybren ; BARTELS, Carina C. M ; SEYNAEVE, Caroline ; HOONING, Maartje J ; KRIEGE, Mieke ; SCHMITZ, Paul I. M ; OOSTERWIJK, Jan C ; KAAS, Reinoutje ; DE KONING, Harry J ; RUTGERS, Emiel J. T ; KLIJN, Jan G. M ; TILANUS-LINTHORST, Madeleine M. A ; BOETES, Carla ; LOO, Claudette E ; WASSER, Martin N. J. M ; BERGERS, Elisabeth ; KOK, Theo ; MULLER, Sara H |
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Zeitschrift: | Journal of clinical oncology, Jg. 28 (2010), Heft 36, S. 5265-5273 |
Veröffentlichung: | Alexandria, VA: American Society of Clinical Oncology, 2010 |
Medientyp: | academicJournal |
Umfang: | print, 49 ref |
ISSN: | 0732-183X (print) |
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