Dopamine susceptibility of APO-SUS rats is not per se coupled to HPA-axis activity
In: Physiology & behavior, Jg. 102 (2011), Heft 2, S. 121-125
academicJournal
- print, 18 ref
Zugriff:
A synergistic relationship is thought to exist between hypothalamic-pituitary-adrenal (HPA) axis activity and dopamine neurotransmission. To test whether a high response to dopamine indeed implies a hyperactive HPA-axis, we here used Wistar rats that were selected twice independently (original and replicate lines) for a high or low susceptibility to the dopamine receptor agonist apomorphine (so-called APO-SUS and APO-UNSUS rats, respectively). The APO-SUS rats from the original line displayed a hyperactive HPA-axis in that higher basal and stress-induced adrenocorticotropic hormone (ACTH) levels, and lower basal free-corticosterone levels were observed than those found in the original APO-UNSUS rats. In contrast, the activity of the HPA-axis in the APO-SUS rats from the replicate line did not differ from that in the replicate APO-UNSUS rats. Thus, in the APO-SUS/APO-UNSUS rat model the level of HPA-axis activity is not necessarily causally linked to dopamine responsiveness, implying that a hyperactive HPA-axis is not a prerequisite for a high dopaminergic response.
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Dopamine susceptibility of APO-SUS rats is not per se coupled to HPA-axis activity
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Autor/in / Beteiligte Person: | VAN SCHIJNDEL, Jessica E ; VAN ZWEEDEN, Martine ; VAN LOO, Karen M. J ; LUBBERS, Luuk J ; PESMAN, Gerard J ; SWEEP, Fred C. G. J ; MARTENS, Gerard J. M |
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Zeitschrift: | Physiology & behavior, Jg. 102 (2011), Heft 2, S. 121-125 |
Veröffentlichung: | Amsterdam: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 18 ref |
ISSN: | 0031-9384 (print) |
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