Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients

WALMSLEY, S ; O'ROURKE, K ; et al.

In: Clinical infectious diseases, Jg. 27 (1998), Heft 3, S. 573-581

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Oral ganciclovir prophylaxis decreases the incidence of cytomegalovirus (CMV) disease among persons infected with the human immunodeficiency virus (HIV), but universal prophylaxis is not cost-effective. We evaluated urine and peripheral blood mononuclear cell cultures, a qualitative and quantitative antigenemia assay, and a commercially available CMV DNA hybridization assay for their ability to predict CMV disease in 138 HIV-infected patients. During a median follow-up of 10 months, 23 patients (17%) developed CMV disease. The sensitivity, specificity, positive predictive value, negative predictive value, and mean lead times for the antigenemia assay (with use of a threshold of 8 positive cells per 105 peripheral blood mononuclear cells as a positive) were 74%, 91%, 63%, 95%, and 95 days, respectively. Corresponding figures for the DNA hybridization assay were 91%, 64%, 34%, 97%, and 152 days. These assays can identify patients at increased risk of CMV disease and should allow a strategy of preemptive therapy to be tested.

Titel:	Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients
Autor/in / Beteiligte Person:	WALMSLEY, S ; O'ROURKE, K ; MORTIMER, C ; RACHLIS, A ; FONG, I ; MAZZULLI, T
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Clinical infectious diseases, Jg. 27 (1998), Heft 3, S. 573-581
Veröffentlichung:	Chicago, IL: University of Chicago Press, 1998
Medientyp:	academicJournal
Umfang:	print, 56 ref
ISSN:	1058-4838 (print)
Schlagwort:	Hygiene and public health, epidemiology, occupational medicine Hygiène et santé publique, épidémiologie, médecine du travail Microbiology, infectious diseases Microbiologie, maladies infectieuses Tropical medicine Médecine tropicale Virology Virologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pathologie infectieuse Infectious diseases Viroses Viral diseases Viroses humaines Human viral diseases Viroses du tissu lymphoïde et du sang. Sida Viral diseases of the lymphoid tissue and the blood. Aids Betaherpesvirinae Herpesviridae Immunodéficit Immune deficiency Inmunodeficiencia Immunopathologie Immunopathology Inmunopatología Infection Infección Virose Viral disease Virosis Virus Biologie moléculaire Molecular biology Biología molecular Complication Complicación Culture cellulaire Cell culture Cultivo celular Cytomegalovirus humain Human cytomegalovirus Evaluation performance Performance evaluation Evaluación prestación Exploration microbiologique Microbiological investigation Análisis microbiológico Homme Human Hombre Hybridation moléculaire Molecular hybridization Hibridación molecular Infection opportuniste Opportunistic infection Infección oportunista Mononucléaire Mononuclear cell Mononuclear SIDA AIDS Sensibilité Sensitivity Sensibilidad Spécificité Specificity Especificidad Urine Orina Valeur prédictive Predictive value Valor predictivo Virémie Viremia
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Medicine, Public Health Sciences, Ophthalmology, and Pathobiology and Laboratory Medicine, University of Toronto and Toronto Hospital, Toronto, Ontario, Canada ; Mount Sinai Hospital, Toronto, Ontario, Canada ; St. Michael's Hospital, Toronto, Ontario, Canada ; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Rights: Copyright 1998 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Infectious pathology

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