Blood Pressure and Cardiovascular Disease Risk in the Veterans Affairs Diabetes Trial
In: Diabetes care, Jg. 34 (2011), Heft 1, S. 34-38
Online
academicJournal
- print, 16 ref
Zugriff:
OBJECTIVE - Blood pressure ranges associated with cardiovascular disease (CVD) events in advanced type 2 diabetes are not clear. Our objective was to determine whether baseline and follow-up (On-Study) systolic blood pressure (SBP), diastolic blood pressure (DBP), and SBP combined with DBP predict CVD events in the Veterans Affairs Diabetes Trial (VADT). RESEARCH DESIGN AND METHODS — Participants in the VADT (n = 1,791) with hypertension received stepped treatment to maintain blood pressure below the target of 130/80 mmHg in standard and intensive glycemic treatment groups. Blood pressure levels of all subjects at baseline and On-Study were analyzed to detect associations with CVD risk. The primary outcome was the time from randomization to the first occurrence of myocardial infarction, ] stroke, congestive heart failure, surgery for vascular disease, inoperable coronary disease, amputation for ischemic gangrene, or CVD death. RESULTS - Separated SBP ≥140 mmHg had significant risk at baseline (hazards ratio [HR] 1.508, P < 0.001) and On-Study (HR 1.469, P = 0.002). DBP < 70 mmHg increased CVD events at baseline (HR 1.482, P < 0.001) and On-Study (HR 1.491, P < 0.001). Combined blood pressure categories indicated high risk for CVD events for SBP ≥140 with DBP <70 mmHg at baseline (HR 1.785, P = 0.03) and On-Study (HR 2.042, P = 0.003) and nearly all SBP with DBP <70 mmHg. CONCLUSIONS — Increased risk of CVD events with SBP ≥ 140 mmHg emphasizes the urgency for treatment of systolic hypertension. Increased risk with DBP <70 mmHg, even when combined with SBP in guideline-recommended target ranges, supports a new finding in patients with type 2 diabetes. The results emphasize that DBP <70 mmHg in these patients was associ- j ated with elevated CVD risk and may best be avoided.
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Blood Pressure and Cardiovascular Disease Risk in the Veterans Affairs Diabetes Trial
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Autor/in / Beteiligte Person: | ANDERSON, Robert J ; BAHN, Gideon D ; MORITZ, Thomas E ; KAUFMAN, Derrick ; ABRAIRA, Carlos ; DUCKWORTH, William ; VADT STUDY, GROUP |
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Zeitschrift: | Diabetes care, Jg. 34 (2011), Heft 1, S. 34-38 |
Veröffentlichung: | Alexandria, VA: American Diabetes Association, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 16 ref |
ISSN: | 0149-5992 (print) |
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