Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: A preliminary report
In: Journal of ethnopharmacology, Jg. 133 (2011), Heft 2, S. 543-550
academicJournal
- print, 1/4 p
Zugriff:
Aim of the study: The purpose of this study was to evaluate the efficacy and safety of a topical Chinese herbal medicine (CHM) compound Tangzu Yuyang Ointment (TYO) for treatment of chronic diabetic foot ulcers. Materials and methods: This multi-center, prospective, randomized, controlled and add-on clinical trial was conducted at seven centers in the China mainland. Fifty-seven patients with chronic diabetic foot ulcers of Wagner's ulcer grade 1-3 were enrolled in this study. Patients who were randomly assigned to the control group (n=28) received standard wound therapy (SWT), whereas those randomized to the treatment group (n= 28) received SWT plus topical TYO. Only 48 patients who finished 24 weeks of observations were entered for data analysis. Results: The TYO and SWT groups were comparable for baseline characteristics. Ulcer improvement was 79.2% in the TYO group and 41.7% in the SWT group (P = 0.017) at 12 weeks, and 91.7% vs. 62.5% (P=0.036) at 24 weeks. The number of ulcers that were completely healed at 4,12 and 24 weeks was similar in both groups, as were the numbers of adverse events. Healing time was 96 ± 56 days (n = 19) in the TYO group and 75 ± 53 days (n = 14) in the SWT group (P = 0.271). Conclusion: TYO plus SWT is more effective than SWT in the management of chronic diabetic foot ulcers and has few side-effects.
Titel: |
Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: A preliminary report
|
---|---|
Autor/in / Beteiligte Person: | SHUFA, LI ; JIANYONG, ZHAO ; RICHENG, YU ; MINGJUN, CHEN ; XIA, WANG ; YE, WANG ; BING, CHEN ; JIANPING, LIU ; FEI, XIANG ; DEBIN, LU ; BAOYING, LIU ; JING, XU ; HUIMIN, ZHANG ; QIAN, ZHANG ; XIANWEN, LI |
Link: | |
Zeitschrift: | Journal of ethnopharmacology, Jg. 133 (2011), Heft 2, S. 543-550 |
Veröffentlichung: | Shannon: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 1/4 p |
ISSN: | 0378-8741 (print) |
Schlagwort: |
|
Sonstiges: |
|