Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides
In: Bioorganic & medicinal chemistry letters (Print), Jg. 21 (2011), Heft 4, S. 1122-1125
academicJournal
- print, 26 ref
Zugriff:
The synthesis and biophysical properties of R-6'-Me-α-L-LNA, which has a methyl group in the (R) configuration on the 2',4'-bridging substituent of α-L-LNA, is reported. The synthesis of the uracil nucleobase phosphoramidite was efficiently accomplished in 14 steps and 8 chromatographic purifications starting from a known sugar intermediate. Biophysical evaluation revealed that substitution along the edge of the major groove does not impair the high affinity duplex forming ability of α-L-LNA modified oligonucleotides.
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Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides
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Autor/in / Beteiligte Person: | SETH, Punit P ; JINGHUA, YU ; ALLERSON, Charles R ; BERDEJA, Andres ; SWAYZE, Eric E |
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Zeitschrift: | Bioorganic & medicinal chemistry letters (Print), Jg. 21 (2011), Heft 4, S. 1122-1125 |
Veröffentlichung: | Amsterdam: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 26 ref |
ISSN: | 0960-894X (print) |
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