Familial Tendency and Risk of Nasopharyngeal Carcinoma in Taiwan: Effects of Covariates on Risk
In: American journal of epidemiology, Jg. 173 (2011), Heft 3, S. 292-299
Online
academicJournal
- print, 35 ref
Zugriff:
In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses.
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Familial Tendency and Risk of Nasopharyngeal Carcinoma in Taiwan: Effects of Covariates on Risk
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Autor/in / Beteiligte Person: | HSU, Wan-Lun ; YU, Kelly J ; LOU, Pei-Jen ; WANG, Cheng-Ping ; HONG, Ji-Hong ; LEU, Yi-Shing ; TSAI, Ming-Hsui ; SU, Mao-Chang ; TSAI, Sen-Tien ; CHAO, Wen-Yuan ; GER, Luo-Ping ; CHEN, Peir-Rong ; CHIEN, Yin-Chu ; YANG, Czau-Siung ; HILDESHEIM, Allan ; DIEHL, Scott R ; CHEN, Chien-Jen ; CHIANG, Chun-Ju ; CHENG, Yu-Juen ; CHEN, Jen-Yang ; LIU, Mei-Ying ; CHOU, Sheng-Ping ; YOU, San-Lin ; HSU, Mow-Ming |
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Zeitschrift: | American journal of epidemiology, Jg. 173 (2011), Heft 3, S. 292-299 |
Veröffentlichung: | Cary, NC: Oxford University Press, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 35 ref |
ISSN: | 0002-9262 (print) |
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