Paediatric Hodgkin's disease in Spain : association with Epstein-Barr virus strains carrying latent membrane protein-1 oncogene deletions and high frequency of dual infections
In: British journal of haematology, Jg. 103 (1998), Heft 1, S. 129-136
Online
academicJournal
- print, 1 p.3/4
Zugriff:
The present report analyses the distribution of 30-base pair (bp) latent membrane protein-1 (LMP-1) oncogene deletions in 24 cases of Epstein-Barr virus (EBV)-positive paediatric Hodgkin's disease (HD) and 39 normal controls. The 30 bp deletion was identified in 19/24 paediatric HD cases (79.2%), of which seven (29.2%) showed the deleted fragment alone, whereas in the remaining 12 (50%) it was accompanied by the nondeleted fragment. Conversely, the deletion was found in 8/22 (36.4%) EBV-positive healthy children, in two (9.1%) of whom the deleted fragment was alone, and was coinfecting with the nondeleted fragment in the other six (27.3%). The LMP-1 deletion was significantly associated with paediatric HD, both including dual infections (P=0.006) or excluding them (P=0.01). Type 2 EBV was carried by 25% of HD children, whereas all controls harboured type 1 EBV. The 30bp deletion was present in all the paediatric HD specimens that contained type 2 EBV, suggesting that a deleted type 2 EBV strain may be more tumourigenic than a nondeleted type 2 EBV strain. These findings indicate that EBV strains carrying a 30 bp deletion in the third exon of the LMP-1 oncogene may have a more important role in the pathogenesis of paediatric HD than full-length EBV strains. I)ual infection by LMP-1 deleted and nondeleted EBV strains is a frequent event both in healthy children and in the paediatric HD population.
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Paediatric Hodgkin's disease in Spain : association with Epstein-Barr virus strains carrying latent membrane protein-1 oncogene deletions and high frequency of dual infections
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Autor/in / Beteiligte Person: | SANTON, A ; MARTIN, C ; MANZANAL, A. I ; PRECIADO, M. V ; BELLAS, C |
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Zeitschrift: | British journal of haematology, Jg. 103 (1998), Heft 1, S. 129-136 |
Veröffentlichung: | Oxford: Blackwell, 1998 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.3/4 |
ISSN: | 0007-1048 (print) |
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