Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
In: Oncogene (Basingstoke), Jg. 30 (2011), Heft 19, S. 2242-2251
Online
academicJournal
- print, 1/2 p
Zugriff:
The c-Myc transcription factor activates a cascade of downstream targets to form a complex transcriptional program that ultimately leads to cellular transformation. Although a large number of protein-encoding genes as well as non-coding RNAs were identified as Myc targets, only a few have been validated to be functionally important for c-Myc-driven transformation. Here, we identify a micro-RNA (miRNA), miR-378, as a novel target of the c-Myc oncoprotein that is able to cooperate with activated Ras or HER2 to promote cellular transformation. Mechanistically, miR-378 achieves this oncogenic effect, at least in part, by targeting and inhibiting the anti-proliferative BTG family member, TOB2, which is further elucidated as a candidate tumor suppressor to transcriptionally repress proto-oncogene cyclin D1. Therefore, our study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation.
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Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation
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Autor/in / Beteiligte Person: | FENG, M ; LI, Z ; AAU, M ; WONG, C. H ; YANG, X ; YU, Q |
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Zeitschrift: | Oncogene (Basingstoke), Jg. 30 (2011), Heft 19, S. 2242-2251 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 1/2 p |
ISSN: | 0950-9232 (print) |
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