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Sources of phthalates other than Polyvinyl chloride (PVC) related products are scarcely documented in Mexico. The objective of our study was to explore the association between urinary levels of nine phthalate metabolites and the use of personal care products. Subjects included 108 women who participated as controls in an ongoing population-based case-control study of environmental factors and genetic susceptibility to breast cancer in northern Mexico. Direct interviews were performed to inquire about sociodemographic characteristics, reproductive history, use of personal care products, and diet. Phthalate metabolites measured in urine by high performance liquid chromatography-isotope dilution tandem mass spectrometry were monoethyl phthalate (MEP), monobenzyl phthalate (MBzP), mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), mono-3-carboxypropyl phthalate (MCPP) as well as mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP) that are metabolites of di-ethylhexyl phthalate (DEHP). Detectable urinary concentrations of phthalate metabolites varied from 75% (MEHP) to 100% (MEP, MBP, MEOHP, MEHHP and MECPP). Medians of urinary concentrations of some phthalate metabolites were significantly higher among users of the following personal care products compared to nonusers: body lotion (MEHHP, MECPP and sum of DEHP metabolites (ΣDEHP)), deodorant (MEHP and ΣDEHP), perfume (MiBP), anti-aging facial cream (MEP, MBP and MCPP) and bottled water (MCPP, MEHHP and MEOHP). Urinary concentrations of MEP showed a positive relationship with the number of personal care products used. Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact.

Titel:	Personal care product use and urinary levels of phthalate metabolites in Mexican women
Autor/in / Beteiligte Person:	ROMERO-FRANCO, Michelle ; HERNANDEZ-RAMIREZ, Raúl U ; CALAFAT, Antonia M ; CEBRIAN, Mariano E ; NEEDHAM, Larry L ; TEITELBAUM, Susan ; WOLFF, Mary S ; LOPEZ-CARRILLO, Lizbeth
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Environment international, Jg. 37 (2011), Heft 5, S. 867-871
Veröffentlichung:	Oxford: Elsevier, 2011
Medientyp:	academicJournal
Umfang:	print, 3/4 p
ISSN:	0160-4120 (print)
Schlagwort:	Ecology Ecologie Environment Environnement Geology Géologie Pollution Toxicology Toxicologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Toxicologie des produits domestiques et cosmétiques Domestic and cosmetic products toxicology Toxicologie des polluants de l'environnement Environmental pollutants toxicology Tumeurs Tumors Carcinogenèse, carcinogènes et anticarcinogènes Carcinogenesis, carcinogens and anticarcinogens Agents chimiques Chemical agents Composé organique Organic compounds Compuesto orgánico Homme Human Hombre Carcinogène Carcinogen Carcinógeno Cosmétique Cosmetic Cosmético Epidémiologie Epidemiology Epidemiología Femme Woman Mujer Métabolite Metabolite Metabolito Perturbateur endocrinien Endocrine disruptor Disruptor endocrino Produit dégradation Degradation product Producto degradación Santé publique Public health Salud pública Urine Orina Phtalate Phtalique acide ester Mexican women Personal care products Phthalates
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Center of Population Health Research, National Institute of Public Health, Mexico, Avenida Universidad No. 655, Col. Santa Maria Ahuacatitlán, Cerrada los Pinos y Caminera, CP 62100, Cuernavaca, Morelos, Mexico ; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA, United States ; Departamento de Toxicologia. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Avenida Instituto Politécnico Nacional 2508 Col San Pedro, Zacatenco, 07360, D.F, Mexico ; Center for Children's Environmental Health and Disease Prevention Research, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029―6574, United States Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pollution ; Toxicology ; Tumours

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Personal care product use and urinary levels of phthalate metabolites in Mexican women