Einzeltreffer — DigiBib

Background: Early withdrawal of steroids after liver transplantation has benefits, but rarely is total avoidance of steroids used. We evaluated long-term results of patients with ab initio monotherapy with cyclosporin (CYA) vs. tacrolimus (TAC), in randomized and cohort studies. Methods: We evaluated long-term outcomes in 66 adults randomized to TAC or CYA and 94 subsequent patients who received TAC. Protocol liver biopsies were performed. Rejection was treated with three 1 g/d methylprednisolone. Further rejection after two courses of methylprednisolone was defined as monotherapy failure. Results: Actuarial five-yr survival was 68% in TAC and 70% CYA. Monotherapy failed in 8% TAC and 13% CYA patients; no rejection in 24% TAC and 19% CYA patients; 42% TAC and 33% CYA patients were not exposed to any steroids. Rejection episodes were less with TAC, compared to CYA: mean 1.8 vs. 2.5, p = 0.042. Chronic rejection occurred in only 4 (11%) CYA patients. During follow-up of median 97 months (range: 0.06-145), there were 16 (44%) deaths in CYA and 48 (39%) in TAC patients (p > 0.05). Conclusions: TAC monotherapy ab initio is a viable immunosuppressive strategy in liver transplantation and was associated with lower rejection rates and renal complications, compared to CYA.

Titel:	Long-term follow-up of immunosuppressive monotherapy in liver transplantation: tacrolimus and microemulsified cyclosporin
Autor/in / Beteiligte Person:	CHOLONGITAS, Evangelos ; SHUSANG, Vibhakorn ; BURROUGHS, Andrew K ; GERMANI, Giacomo ; TSOCHATZIS, Emmanuel ; LUISA RAIMONDO, Maria ; MARELLI, Laura ; SENZOLO, Marco ; DAVIDSON, Brian R ; PATCH, David ; ROLLES, Keith
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Clinical transplantation, Jg. 25 (2011), Heft 4, S. 614-624
Veröffentlichung:	Hoboken, NJ: Wiley, 2011
Medientyp:	academicJournal
Umfang:	print, 33 ref
ISSN:	0902-0063 (print)
Schlagwort:	Graft, transplantation Greffe, transplantation Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Immunologie fondamentale Fundamental immunology Immunologie de tissu, d'organe, des greffes Tissue, organ and graft immunology Sciences medicales Medical sciences Endocrinopathies Pancréas endocrine. Cellules apud (pathologie) Endocrine pancreas. Apud cells (diseases) Diabète. Anomalie tolérance glucose Diabetes. Impaired glucose tolerance Etiopathogénie. Dépistage. Explorations. Résistance tissu cible Etiopathogenesis. Screening. Investigations. Target tissue resistance Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Chirurgie de l'appareil digestif Surgery of the digestive system Foie, voies biliaires, pancréas, circulation portale, rate Liver, biliary tract, pancreas, portal circulation, spleen Appareil digestif Digestive system Aparato digestivo Cancer Cáncer Chirurgie Surgery Cirugía Endocrinopathie Endocrinopathy Endocrinopatía Enzyme Enzima IMP dehydrogenase Inhibiteur enzyme Enzyme inhibitor Inhibidor enzima Inhibiteur synthèse protéique Protein synthesis inhibitor Inhibidor síntesis proteica Lactone Lactona Macrolide Macrólido Oxidoreductases Pathologie de l'appareil circulatoire Cardiovascular disease Aparato circulatorio patología Pathologie de l'appareil digestif Digestive diseases Aparato digestivo patología Pathologie des artères Arterial disease Arteria patología Pathologie des vaisseaux sanguins Vascular disease Vaso sanguíneo patología Pathologie du foie Hepatic disease Hígado patología Thiopurine dérivé Thiopurine derivatives Derivado de la tiopurina Tumeur maligne Malignant tumor Tumor maligno Acide mycophénolique Mycophenolic acid Acido micofenólico Antibactérien Antibacterial agent Antibacteriano Antibiotique Antibiotic Antibiótico Antiviral Artère hépatique Hepatic artery Arteria hepática Azathioprine Azatioprina Base de données Database Base dato Cancer du foie Liver cancer Cáncer del hígado Carcinome hépatocellulaire Hepatocellular carcinoma Carcinoma hepatocelular Ciclosporine Ciclosporin Ciclosporina Diabète Diabetes mellitus Diabetes Etude longitudinale Follow up study Estudio longitudinal Foie Liver Hígado Homotransplantation Homotrasplante Hôpital Hospital Immunodépresseur Immunosuppressive agent Inmunodepresor Immunodépression Immunosuppression Inmunodepresión Immunomodulateur Immunomodulator Inmunomodulador Inhibiteur de la calcineurine Calcineurin inhibitor Inhibidor calcineurina Long terme Long term Largo plazo Mofétil Mofetil Mofetilo Mycophénolate mofétil Mycophenolate mofetil Micofenolato mofetil Surveillance Vigilancia Tacrolimus Tacrolimús Thrombose des artères Artery thrombosis Thrombose arteria Traitement Treatment Tratamiento Monothérapie Monotherapy Transplantation hépatique Liver transplantation CNI,calcineurin inhibitor: CYA DM HAT, hepatic artery thrombosis HCC LT MMF, mycophenolate mofetil RFH Royal Free Hospital TAC UNOS United Network for Organ Sharing azathioprine cyclosporin diabetes mellitus hepatocellular carcinoma immunosuppression liver transplantation microemulsified cyclosporin monotherapy tacrolimus Abbreviations: AZA tacrolimus
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: The Royal Free Sheila Sherlock Liver Centre and Department of Surgery, Royal Free Hospital, London, United Kingdom ; Fourth Department of Internal Medicine, Hippocration General Hospital of Thessaloniki, Thessaloniki, Greece Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Endocrinopathies ; Fundamental immunology ; Surgery (generalities). Transplants, organs and tissues grafting. Graft pathologies

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Long-term follow-up of immunosuppressive monotherapy in liver transplantation: tacrolimus and microemulsified cyclosporin