Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile
In: Journal of the American Academy of Child and Adolescent Psychiatry, Jg. 50 (2011), Heft 8, S. 807-817
academicJournal
- print, 61 ref
Zugriff:
Objective:: A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD). Method: Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK. Results: CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. Conclusions: We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
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Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile
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Autor/in / Beteiligte Person: | MICK, Eric ; MCGOUGH, James ; LOO, Sandra ; DOYLE, Alysa E ; WOZNIAK, Janet ; WILENS, Timothy E ; SMALLEY, Susan ; MCCRACKEN, James ; BIEDERMAN, Joseph ; FARAONE, Stephen V |
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Zeitschrift: | Journal of the American Academy of Child and Adolescent Psychiatry, Jg. 50 (2011), Heft 8, S. 807-817 |
Veröffentlichung: | Maryland Heights, MO: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 61 ref |
ISSN: | 0890-8567 (print) |
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