Efficacy and safety of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as induction chemotherapy for elderly patients with high-risk MDS or AML transformed from MDS
In: Journal of cancer research and clinical oncology, Jg. 137 (2011), Heft 10, S. 1563-1569
Online
academicJournal
- print, 3/4 p
Zugriff:
Background To evaluate the efficacy and toxicity of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as an induction chemotherapy for elderly patients with high-risk MDS or acute myeloid leukemia transformed from MDS (MDS-AML). Methods Thirty-three untreated patients (21 high-risk MDS and 12 MDS-AML) were enrolled in this study. Each patient was administered with the CHG regimen comprised of low-dose cytarabine (25 mg/day, days 1-14) and homoharringtonine (1 mg/day, days 1-14) by intravenous continuous infusion in combination with G-CSF (300 μg/day) by subcutaneous injection from day 0 until neutrophil count recovery to 2.0 x 109/L. Results The overall response rate (OR) was 66.7% after one course of the CHG regimen with 19 patients reaching CR (57.6%) and 3 patients reaching partial remission (PR) (9.1%). The median overall survival (OS) was 15.0 months. Patients with normal serum lactate dehydrogenase (LDH) appeared longer median OS when compared to patients with high LDH level (18 months vs. 5 months, P = 0.011). Grade 3/4 thrombocytopenia occurred in 28% of patients, neutropenia in 34%. No treatment-related deaths occurred during the induction therapy. Conclusions These data suggest that the CHG priming regimen is effective and safe as a novel induction therapy for elderly patients with high-risk MDS and MDS-AML. The results need to be conformed in further study involving a larger cohort of patients.
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Efficacy and safety of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as induction chemotherapy for elderly patients with high-risk MDS or AML transformed from MDS
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Autor/in / Beteiligte Person: | LINGYUN, WU ; XIAO, LI ; JIYING, SU ; QI, HE ; XI, ZHANG ; CHUNKANG, CHANG ; QUAN, PU |
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Zeitschrift: | Journal of cancer research and clinical oncology, Jg. 137 (2011), Heft 10, S. 1563-1569 |
Veröffentlichung: | Heidelberg: Springer, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 3/4 p |
ISSN: | 0171-5216 (print) |
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