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Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L. The effects and possible mechanisms of astilbin on hyperuricemia and nephropathy rats were elucidated in this study. Different dosages of astilbin (1.25, 2.5, and 5.0 mg/kg) were administered to 10% fructose-induced hyperuricemic rats. The results demonstrated that astilbin significantly decreased the serum uric acid (Sur) level by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) but not inhibiting the xanthine oxidase (XOD) activity. In addition, kidney function parameters such as serum creatinine (Scr) and blood urea nitrogen (BUN) were recovered in astilbin-treated hyperuricemic rats. Further investigation indicated that astilbin prevented the renal damage against the expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) and also exerted a renal protective role by inhibiting formation of monosodium urate (MSU) and production of prostaglandin E2 (PGE2) and interleukin-1 (IL-1). These findings provide potent evidence for astilbin as a safe and promising lead compound in the development of a disease-modifying drug to prevent hyperuricemia and nephropathy.

Titel:	Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats
Autor/in / Beteiligte Person:	CHEN, Lvyi ; ZHOU, LAN ; YONGQIANG, ZHOU ; FEI, LI ; XIN, ZHANG ; CHUNFENG, ZHANG ; ZHONGLIN, YANG ; PING, LI
Link:	View record from PASCAL Archive
Zeitschrift:	Planta medica, Jg. 77 (2011), Heft 16, S. 1769-1773
Veröffentlichung:	Stuttgart: Thieme, 2011
Medientyp:	academicJournal
Umfang:	print, 25 ref
ISSN:	0032-0943 (print)
Schlagwort:	Asie Asia Chine China Pharmacology drugs Pharmacologie, galénique Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Pharmacologie générale General pharmacology Pharmacognosie. Homéopathie. Aliment santé Pharmacognosy. Homeopathy. Health food Angiospermae Cytokine Citoquina Flavonoïde Flavonoid Flavonoide Maladie métabolique Metabolic diseases Metabolismo patología Mammalia Monocotyledones Pathologie de l'appareil urinaire Urinary system disease Aparato urinario patología Pathologie du rein Kidney disease Riñón patología Phénols Phenols Fenoles Polyphénol Polyphenol Polifenol Rodentia Spermatophyta Vertebrata Acide urique Uric acid Urico ácido Animal Dérivé de la flavanone Flavanone derivatives Flavanona derivado Dérivé de la purine Purine derivatives Purina derivado Fructose Fructosa Glycoside Glicósido Hyperuricémie Hyperuricemia Hiperuricemia Interleukine 1 Interleukin 1 Interleuquina 1 Liliaceae Médecine traditionnelle Folk medicine Medicina tradicional Néphropathie Nephropathy Nefropatía Origine végétale Plant origin Origen vegetal Pharmacognosie Pharmacognosy Farmacognosia Plante médicinale Medicinal plant Planta medicinal Purine Purina Rat Rata Astilbine Médecine traditionnelle chinoise Rhamnopyranoside dérivé Smilax china Smilaceae astilbin connective tissue growth factor hyperuricemia interleukin-1 nephropathy Subject Geographic: Asie Asia Chine China
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing, China ; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: General pharmacology

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Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats