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The effects of alkali dissociation on the molecular conformation and immunomodulatory activity of longan pulp polysaccharide (LPI) were investigated to explore their possible relationship. The molecular conformations of LPI and its degraded derivatives (LPI1 and LPI2) were examined by size exclusion chromatography combined with multi-angle laser light scattering (SEC-MALLS), Congo red test and atomic force microscopy (AFM). The results confirmed the transformation of LPI from compact sphere-like conformation to slightly dissociated sphere-like conformation (LPI1) or single-helix chain (LPI2). Compared with the control, splenocyte proliferation and NK cell cytotoxicity were significantly enhanced by LPI1 and LPI2 (P<0.05). although they were not stimulated by LPI in 100-400 μg/mL (P> 0.05). All the polysaccharides could significantly enhance macrophage phagocytosis at 100 or 200 μg/mL (P<0.05). Single-helix chain might play an important role in activating lymphocytes and NK cells, but having weak contribution to macrophage phagocytosis.

Titel:	Effects of alkali dissociation on the molecular conformation and immunomodulatory activity of longan pulp polysaccharide (LPI)
Autor/in / Beteiligte Person:	YANG, YI ; ZHANG, Ming-Wei ; LIAO, Sen-Tai ; ZHANG, Rui-Fen ; DENG, Yuan-Yuan ; WEI, Zhen-Cheng ; BAO, YANG
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Carbohydrate polymers, Jg. 87 (2012), Heft 2, S. 1311-1317
Veröffentlichung:	Kidlington: Elsevier, 2012
Medientyp:	academicJournal
Umfang:	print, 3/4 p
ISSN:	0144-8617 (print)
Schlagwort:	Polymers, paint and wood industries Polymères, industries des peintures et bois Sciences exactes et technologie Exact sciences and technology Sciences appliquees Applied sciences Physicochimie des polymeres Physicochemistry of polymers Polymères d'origine naturelle Natural polymers Amidon et polyosides divers Starch and polysaccharides Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Immunomodulateurs Immunomodulators Angiospermae Dicotyledones Sapindaceae Spermatophyta Activité biologique Biological activity Actividad biológica Base chimique Chemical base Base química Cellule NK Natural killer cell Célula NK Conformation Conformación Cytotoxicité Cytotoxicity Citotoxicidad Dimocarpus longan Etude expérimentale Experimental study Estudio experimental Hydroxyde de sodium Sodium hydroxide Sodio hidróxido Immunomodulateur Immunomodulator Inmunomodulador In vitro Macrophage Macrófago Multiplication cellulaire Cell proliferation Multiplicación celular Méthode en solution Growth from solution Método en solución Origine végétale Plant origin Origen vegetal Oside polymère Oside polymer Osido polímero Phagocytose Phagocytosis Fagocitosis Pulpe fruit Fruit pulp Pulpa fruto Rayon giration Radius of gyration Radio giro Relation masse moléculaire propriété Molecular weight property relation Relación masa molecular propiedad Relation structure activité Structure activity relation Relación estructura actividad Solution aqueuse Aqueous solution Solución acuosa Splénocyte Splenocyte Esplenocito Traitement chimique Chemical treatment Tratamiento químico Alkali dissociation Immunomodulatory activity Longan pulp Polysaccharide
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Key Laboratory of Functional Food Ministry of Agriculture, Bio-technical Research Institute Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China ; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China ; South China Botanical Garden. Chinese Academy of Sciences, Guangzhou 510650, China Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pharmacological treatments ; Physical chemistry of polymers

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Effects of alkali dissociation on the molecular conformation and immunomodulatory activity of longan pulp polysaccharide (LPI)