Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity
In: Circulation research, Jg. 109 (2011), Heft 12, S. 1387-1395
Online
academicJournal
- print, 28 ref
Zugriff:
Rationale: Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present in human atherosclerotic lesions, their role in atherosclerosis remains elusive. Objective: To investigate the role of PDC in atherosclerosis. Methods and Results: We show that PDC are scarcely present in human atherosclerotic lesions and almost absent in mouse plaques. Surprisingly, PDC depletion by 120G8 mAb administration was seen to promote plaque T-cell accumulation and exacerbate lesion development and progression in LDLr―/― mice. PDC depletion was accompanied by increased CD4+ T-cell proliferation, interferon-γ expression by splenic T cells, and plasma interferon-γ levels. Lymphoid tissue PDC from atherosclerotic mice showed increased indoleamine 2,3-dioxygenase (IDO) expression and IDO blockage abrogated the PDC suppressive effect on T-cell proliferation. Conclusions: Our data reveal a protective role for PDC in atherosclerosis, possibly by dampening T-cell proliferation and activity in peripheral lymphoid tissue, rendering PDC an interesting target for future therapeutic interventions.
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Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity
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Autor/in / Beteiligte Person: | DAISSORMONT, Isabelle T. M. N ; CHRIST, Anette ; DAEMEN, Mat ; LUTGENS, Esther ; HALVORSEN, Bente ; AUKRUST, Pal ; JANSSEN, Edith ; BIESSEN, Erik A. L ; TEMMERMAN, Lieve ; SAMPEDRO MILLARES, Stefan ; SEIJKENS, Tom ; MANCA, Marco ; ROUSCH, Mat ; POGGI, Marjorie ; BOON, Louis ; VAN DER LOOS, Chris |
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Zeitschrift: | Circulation research, Jg. 109 (2011), Heft 12, S. 1387-1395 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2011 |
Medientyp: | academicJournal |
Umfang: | print, 28 ref |
ISSN: | 0009-7330 (print) |
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