Reversal of UVA Skin Photosensitivity and DNA Damage in Kidney Transplant Recipients by Replacing Azathioprine

HOFBAUER, G. F. L ; ATTARD, N. R ; et al.

In: American journal of transplantation (Print), Jg. 12 (2012), Heft 1, S. 218-225

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Azathioprine is associated with enhanced skin photosensitivity to ultraviolet A (UVA) and leads to incorporation of 6-thioguanine (6-TG) into DNA of dividing cells. Unlike canonical DNA, 6-TG DNA is damaged by UVA, which comprises more than 90% of the ultraviolet reaching earth. Skin photosensitivity to UVA and UVB was measured in 48 kidney transplant patients immunosuppressed either by azathioprine (n = 32) or mycophenolate (n = 16). In 23 patients, azathioprine was subsequently replaced by mycophenolate and skin photosensitivity, DNA 6-TG content in peripheral blood mononuclear cells, and susceptibility to UVA-induced DNA damage were monitored for up to 2 years. The mean minimal erythema dose to UVA on azathioprine was twofold lower than on mycophenolate. Three months after replacing azathioprine by mycophenolate mofetil, the minimal erythema dose to UVA had increased from 15 to 25 J/cm2 (p < 0.001) accompanied by reduced DNA 6-TG content. P53 protein expression in irradiated skin indicated reduced susceptibility to UVA-induced DNA damage. 6-TG DNA in peripheral blood mononuclear cells remained measurable for over 2 years. Replacing azathioprine selectively reduced the skin photosensitivity to UVA, attenuated UVA-induced skin DNA damage, and is likely based on incorporated 6-TG in DNA.

Titel:	Reversal of UVA Skin Photosensitivity and DNA Damage in Kidney Transplant Recipients by Replacing Azathioprine
Autor/in / Beteiligte Person:	HOFBAUER, G. F. L ; ATTARD, N. R ; FRENCH, L. E ; WÜTHRICH, R. P ; KARRAN, P ; SERRA, A. L ; HARWOOD, C. A ; MCGREGOR, J. M ; DZIUNYCZ, P ; IOTZOVA-WEISS, G ; STRAUB, G ; MEYER, R ; KAMENISCH, Y ; BERNEBURG, M
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	American journal of transplantation (Print), Jg. 12 (2012), Heft 1, S. 218-225
Veröffentlichung:	Hoboken, NJ: Wiley, 2012
Medientyp:	academicJournal
Umfang:	print, 26 ref
ISSN:	1600-6135 (print)
Schlagwort:	Graft, transplantation Greffe, transplantation Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Dermatologie Dermatology Dermatoses diverses. Peau et pathologie générale. Généralités Skin involvement in other diseases. Miscellaneous. General aspects Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Chirurgie de l'appareil urinaire Surgery of the urinary system Antimétabolite Antimetabolic Antimetabólito Appareil urinaire Urinary system Aparato urinario Chirurgie Surgery Cirugía Dérivé de la purine Purine derivatives Purina derivado Greffe Graft Injerto Pathologie de la peau Skin disease Piel patología Thiopurine dérivé Thiopurine derivatives Derivado de la tiopurina Anticancéreux Antineoplastic agent Anticanceroso Azathioprine Azatioprina DNA Homotransplantation Homotrasplante Immunodépresseur Immunosuppressive agent Inmunodepresor Lésion Lesion Lesión Peau Skin Piel Photosensibilité Photosensitivity Fotosensibilidad Rayonnement UVA UVA radiation Radiación UVA Rein Kidney Riñón Réversibilité Reversibility Reversibilidad Tioguanine Tioguanina Traitement Treatment Tratamiento Transplantation rénale Kidney transplantation Trasplante de riñón 6-thioguanine DNA UVA kidney transplantation skin photosensitivity
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Dermatology, University Hospital Zürich, Switzerland ; Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, United Kingdom ; Division of Nephrology, University Hospital Zürich, Switzerland ; Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom ; Department of Dermatology, University of Tübingen, Tübingen, Germany Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Dermatology ; Surgery (generalities). Transplants, organs and tissues grafting. Graft pathologies

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