The influence of vitamin E and methionine on the activity of enzymes and the morphological picture of liver of rats intoxicated with sodium fluoride

STAWIARSKA-PIETA, Barbara ; BIELEC, Beata ; et al.

In: Food and chemical toxicology, Jg. 50 (2012), Heft 3-4, S. 972-978

academicJournal - print, 3/4 p

The aim of this study was to investigate the effects of vitamin E and methionine on the activity of enzymes regulating carbohydrate metabolism and enzymes associated with glutathione as well as to examine the morphology of the liver in rats exposed to sodium fluoride. The study was conducted in 18 male rats of Wistar strain. The rats were divided into three groups: a control group, which received distilled water and two experimental groups, which received sodium fluoride (10 mg/kg of body mass/24 h) in water solution. Animals in the second experimental group received 3 mg of vitamin E/rat/24 h and 2 mg methionine/rat/24 h. The experiment lasted 35 days. In supernatants obtained after homogenization of rat liver slices, the activity of the following enzymes was assayed: fructose-1,6-biphosphate aldolase (ALD) malate dehydrogenase (MDH), lactate dehydrogenase (LDH), sorbitol dehydrogenase (SDH) the activity of glutathione peroxidase (GPx), glutathione transferase (GST) and glutathione reductase (GR). Pathomorphological evaluation was conducted on preparations made by standard paraffin method, followed by staining with hematoxylin and eosin. The administration of antioxidants counteracted changes in the activity of the enzymes and the morphological abnormalities of the liver induced by NaF. Antioxidants may be important in preventing toxicity of fluoride compounds.

Titel:	The influence of vitamin E and methionine on the activity of enzymes and the morphological picture of liver of rats intoxicated with sodium fluoride
Autor/in / Beteiligte Person:	STAWIARSKA-PIETA, Barbara ; BIELEC, Beata ; BIRKNER, Katarzyna ; BIRKNER, Ewa
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Food and chemical toxicology, Jg. 50 (2012), Heft 3-4, S. 972-978
Veröffentlichung:	Oxford: Elsevier, 2012
Medientyp:	academicJournal
Umfang:	print, 3/4 p
ISSN:	0278-6915 (print)
Schlagwort:	Food science technology Sciences technologies alimentaires Toxicology Toxicologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Aminoacide soufré Sulfur containing aminoacid Aminoácido azufrado Appareil digestif Digestive system Aparato digestivo Composé biochimique Biochemical compound Compuesto bioquímico Composé du fluor Fluorine compound Flúor compuesto Composé du sodium Sodium compound Sodio compuesto Composé minéral Inorganic compound Compuesto inorgánico Mammalia Matière minérale Mineral matter Materia mineral Rodentia Sel minéral Mineral salt Sal inorgánica Soufre Composé organique Sulfur Organic compounds Azufre Compuesto orgánico Thiol Tiol Transferases Vertebrata Activité biologique Biological activity Actividad biológica Anatomopathologie Anatomic pathology Anatomía patológica Animal Enzyme Enzima Fluorure de sodium Sodium fluoride Sodio fluoruro Foie Liver Hígado Glutathione transferase Histopathologie Histopathology Histopatología Méthionine Methionine Metionina Rat Rata Vitamine E Vitamin E Vitamina E Anticarie Enzymes, ALD, MDH, LDH, SDH, GR, GS, GST Histopathology-liver Rats Vitamin E and methionine
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Pathology, Faculty of Pharmacy, Silesian Medical University in Katowice, Sosnowiec, Poland ; Clinical Department of Cardiology at the Silesian Center for Heart Diseases in, Zabrze, Poland ; Department of General Biochemistry, Faculty of Medicine in Zabrze, Silesian Medical University in Katowice, Zabrze, Poland Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Toxicology

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