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The method that is probably the most commonly used worldwide for the determination of total organic isocyanates (NCO) in air is the Health and Safety Executive method, MDHS 25/3, Organic Isocyanates in Air, and its variants. This paper summarizes some of the research and development work carried out by Health and Safety Laboratory on this method since its publication in 1999 with the eventual aim of incorporating this work in an updated version of MDHS 25 (i.e. MDHS 25/4). The work falls into two main areas: use of liquid chromatography/ mass spectrometry (LC/MS) as an alternative to liquid chromatography with electrochemical and ultraviolet/visible detection (LC/EC/UV) and evaluation of 'solid-phase' sampling techniques as an alternative to the impinger-filter combination stated in MDHS 25/3. This paper deals primarily with HDI-based NCO but some comments regarding aromatic NCO (MDI and TDI) are included for completeness. An LC/MS/MS version of MDHS 25/3 has been developed that gives improved performance to the 'classical' version of MDHS 25/3 using EC/UV detection. The LC/ MS/MS offers significant advantages over the EC/UV version of MDHS 25/3 in that it is more sensitive, provides improved identification, and has been found to be easier to use. The solid-phase samplers evaluated were a double-thickness glass-fibre (GFB) filter coated with 1-(2-methoxyphenyl)piperazine (MP) reagent in an IOM (Institute of Occupational Medicine) sampling head ('FIN-MP' sampler) and an MP-impregnated polyurethane foam sponge (PUF) with an MP-coated glass-fibre (GF/A) backup filter also in an IOM sampling head ('Rudzinski' sampler). Both samplers were found to give acceptable performance for the sampling of oligomeric HDI in workplace air and in laboratory simulations when compared to the impinger-filter combination at levels corresponding to the UK short-term limit (70 μg m-3). For practical reasons, the FIN-MP sampler was the preferred alternative.

Titel:	MDHS 25 Revisited: Part 2, Modified Sampling and Analytical Procedures Applied to HDI-Based Isocyanates
Autor/in / Beteiligte Person:	WHITE, John ; JOHNSON, Paul ; PENGELLY, Ian ; KEEN, Chris ; COLDWELL, Matthew
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Annals of occupational hygiene, Jg. 56 (2012), Heft 4, S. 466-480
Veröffentlichung:	Oxford: Oxford University Press, 2012
Medientyp:	academicJournal
Umfang:	print, 1 p.1/4
ISSN:	0003-4878 (print)
Schlagwort:	Europe Europa Royaume-Uni United Kingdom Reino Unido Hygiene and public health, epidemiology, occupational medicine Hygiène et santé publique, épidémiologie, médecine du travail Applied physiology, ergonomics sports medicine Physiologie appliquée, ergonomie, sport Toxicology Toxicologie Sciences exactes et technologie Exact sciences and technology Sciences appliquees Applied sciences Pollution Pollution atmosphérique Atmospheric pollution Méthodes d'analyse Analysis methods Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Toxicologie des produits chimiques et industriels. Maladies professionnelles dues aux toxiques Chemical and industrial products toxicology. Toxic occupational diseases Composés organiques divers Various organic compounds Toxicologie des polluants de l'environnement Environmental pollutants toxicology Air Sante publique. Hygiene-medecine du travail Public health. Hygiene-occupational medicine Médecine du travail Occupational medicine Ergonomie. Poste de travail. Psychologie du travail Ergonomics. Workplace layout. Occupational psychology Prélèvement, méthode analyse polluant, en milieu travail Sampling, pollutant analysis method, on the work place Chromatographie HPLC HPLC chromatography Cromatografía HPLC Chromatographie phase liquide Liquid chromatography Cromatografía fase líquida Dose limite Limit dose Dosis límite Echantillonnage Sampling Muestreo Isocyanate organique Organic isocyanate Isocianato orgánico Lieu travail Work place Lugar trabajo Mesure concentration Concentration measurement Medición concentración Pollution air Air pollution Contaminación aire Procédure Procedure Procedimiento Prélèvement Samplings Toma de muestra Spectrométrie masse Mass spectrometry Espectrometría masa HDI LC/MS MDHS 25/3 MDI MVR isocyanates solid-phase sampling Subject Geographic: Europe Europa Royaume-Uni United Kingdom Reino Unido
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Health and Safety Laboratory, Harpur Hill, Buxton SK17 9JN, United Kingdom Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pollution ; Public health. Hygiene-occupational medicine. Information processing ; Toxicology

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MDHS 25 Revisited: Part 2, Modified Sampling and Analytical Procedures Applied to HDI-Based Isocyanates