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UV radiation from the sun is a potent environmental risk factor in the pathogenesis of skin damage. Much of the skin damage caused by ultraviolet A (UVA) irradiation from the sun is associated with oxidative stress. The aim of this study was to investigate the protective role of ellagic acid (25-75 μM), a natural antioxidant, against UVA (5―20 J/cm2)-induced oxidative stress and apoptosis in human keratinocyte (HaCaT) cells and to reveal the possible mechanisms underlying this protective efficacy. Ellagic acid pre-treatment markedly increased HaCaT cell viability and suppressed UVA-induced ROS generation and MDA formation. Moreover, ellagic acid pre-treatment prevented UVA-induced DNA damage as evaluated by the comet assay. Ellagic acid treatment also significantly inhibited the UVA-induced apoptosis of HaCaT cells, as measured by a reduction of DNA fragmentation, mitochondria dysfunction, ER stress, caspase-3 activation, and Bcl-2/Bax deregulation. Notably, the antioxidant potential of ellagic acid was directly correlated with the increased expression of HO-1 and SOD, which was followed by the downregulation of Keap1 and the augmented nuclear translocation and transcriptional activation of Nrf2 with or without UVA irradiation. Nrf2 knockdown diminished the protective effects of ellagic acid. Therefore, ellagic acid may be useful for the treatment of UVA-induced skin damage.

Titel:	Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes
Autor/in / Beteiligte Person:	HSEU, You-Cheng ; CHOU, Chih-Wei ; SENTHIL KUMAR, K. J ; FU, Ke-Ting ; WANG, Hui-Min ; HSU, Li-Sung ; KUO, Yueh-Hsiung ; WU, Chi-Rei ; CHEN, Ssu-Ching ; YANG, Hsin-Ling
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Food and chemical toxicology, Jg. 50 (2012), Heft 5, S. 1245-1255
Veröffentlichung:	Oxford: Elsevier, 2012
Medientyp:	academicJournal
Umfang:	print, 1 p
ISSN:	0278-6915 (print)
Schlagwort:	Food science technology Sciences technologies alimentaires Toxicology Toxicologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Mutagenèse chimique Chemical mutagenesis Composé organique Organic compounds Compuesto orgánico Enzyme Enzima Lactone Lactona Lumière Light Luz Onde électromagnétique Electromagnetic wave Onda electromagnética Oxidoreductases Oxydant Oxidant Oxidante Phénols Phenols Fenoles Polyphénol Polyphenol Polifenol Rayonnement UV proche Near ultraviolet radiation Radiación ultravioleta próxima Rayonnement UV Ultraviolet radiation Radiación ultravioleta Acide ellagique Ellagic acid Acido elágico Anticancéreux Antineoplastic agent Anticanceroso Antimutagène Antimutagen Antimutágeno Antioxydant Antioxidant Antioxidante Apoptose Apoptosis Environnement physique Physical environment Medio ambiente físico Espèces réactives de l'oxygène Reactive oxygen species Especies reactivas del oxígeno Facteur transcription NF-E2 Transcription factor NF-E2 Factor transcripción NF-E2 Gène Gene Gen Génétique Genetics Genética Heme oxygenase (decyclizing) Homme Human Hombre Hémostatique Hemostatic Hemostático Kératinocyte Keratinocyte Queratinocito Mort cellulaire Cell death Muerte celular Peau Skin Piel Protéine choc thermique Heat shock protein Proteína choque térmico Prévention Prevention Prevención Rayonnement UVA UVA radiation Radiación UVA Stress oxydatif Oxidative stress Estrés oxidativo Heme oxygenase 1 NF-E2-related factor-2 Ultraviolet A
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 40402, Tawain, Province of China ; Institute of Nutrition, China Medical University, Taichung 40402, Tawain, Province of China ; Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, Tawain, Province of China ; Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 40201, Tawain, Province of China ; School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Tawain, Province of China ; Department of Chemistry, National Taiwan University, Taipei 10617, Tawain, Province of China ; Department of Life Sciences, National Central University, Chung-Li 32001, Tawain, Province of China Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Toxicology

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Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes