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Objective: There is currently controversy over the association between serum interleukin-4 and -10 levels and head and neck squamous cell carcinoma in patients of different ethnicity. This study aimed to investigate serum levels of these cytokines in Iranian patients with this pathology, and to analyse correlations with tumour location and tumour stage at diagnosis. Design: Serum cytokines levels were quantified using commercial enzyme-linked immunosorbent assays. Subjects: Study groups comprised 93 untreated patients and 53 healthy donors. Results: Serum interleukin-4 levels were significantly increased in patients compared with controls (p < 0.000), but were not significantly associated with tumour stage. Serum interleukin-10 levels were not raised in patients, nor associated with tumour stage. Conclusion: Serum levels of interleukin-4, but not -10, were increased in Iranian head and neck squamous cell carcinoma patients. These data do not support an association of these cytokines with tumour progression; this is consistent with previous findings.

Titel:	Serum levels of interleukins 4 and 10 in head and neck squamous cell carcinoma
Autor/in / Beteiligte Person:	MOJTAHEDI, Z ; KHADEMI, B ; YEHYA, A ; TALEBI, A ; FATTAHI, M. J ; GHADERI, A
Link:	View record from PASCAL Archive
Zeitschrift:	Journal of laryngology and otology, Jg. 126 (2012), Heft 2, S. 175-179
Veröffentlichung:	Cambridge: Cambridge University Press, 2012
Medientyp:	academicJournal
Umfang:	print, 15 ref
ISSN:	0022-2151 (print)
Schlagwort:	Otorhinolaryngology, stomatology, dentistry Otorhinolaryngologie, stomatologie, dentisterie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Otorhinolaryngologie. Stomatologie Otorhinolaryngology. Stomatology Otorhinolaryngologie (tête cou, généralités et divers) Otorhinolaryngology (head neck, general aspects and miscellaneous) Tumeurs Tumors Cancer Cáncer Pathologie ORL ENT disease ORL patología Tumeur maligne Malignant tumor Tumor maligno Cancer de la tête et du cou Head and neck cancer Cáncer de cabeza y cuello Carcinome épidermoïde de la tête et du cou Head and neck squamous cell carcinoma Carcinoma epidermoideo cabeza cuello Cellule Cell Célula Immunodépression Immunosuppression Inmunodepresión Interleukine 10 Interleukin 10 Interleuquina 10 Interleukine 4 Interleukin 4 Interleuquina 4 ORL ENT Sérum Serum Suero Tête cou Head and neck Cabeza cuello Carcinoma Head And Neck Neoplasms Interleukin-10 Interleukin-4 Squamous Cell
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Otorhinolaryngology. Stomatology

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Serum levels of interleukins 4 and 10 in head and neck squamous cell carcinoma