Einzeltreffer — DigiBib

The chemokine ligand CXC chemokine ligand 16 and its receptor chemokine (C-X-C motif) receptor 6 are up-regulated in many types of cancer and give rise to more aggressive behavior by regulating proliferation and angiogenesis. To clarify the role and clinicopathologic significance of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 expression in gastric carcinoma, their expression was examined by immunohistochemistry of tissue microarrays containing gastric carcinoma and nonneoplastic mucosa, reverse transcription―polymerase chain reaction, and Western blotting and by enzyme-linked immunosorbent assay to determine the CXC chemokine ligand 16 concentration in serum. Expression was compared with the clinicopathologic features of the carcinomas. All carcinoma and epithelial cells showed CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 messenger RNA expression to various degrees. Among 28 pairs of gastric carcinoma and normal tissues, there was higher CXC chemokine ligand 16 expression in carcinoma than in adjacent mucosa (P < .05), whereas the converse was true for chemokine (C-X-C motif) receptor 6 (P < .05). Nuclear CXC chemokine ligand 16 expression correlated inversely with the depth of invasion, lymphatic invasion, Union Internationale Contre le Cancer stage, and favorable prognosis. The serum CXC chemokine ligand 16 concentration was lower in male patients or patients 55 years or older than in female or younger patients, respectively (P < .05). Patients with lymphatic invasion or mixed-type carcinoma showed lower CXC chemokine ligand 16 concentrations than those with no lymphatic invasion or with diffuse-type carcinoma (P < .05). Aberrant expression of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 might be involved in gastric carcinogenesis. The expression and serum concentration of CXC chemokine ligand 16 could indicate the aggressiveness and prognosis of gastric carcinomas.

Titel:	Role and clinicopathologic significance of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 expression in gastric carcinomas
Autor/in / Beteiligte Person:	XING, Ya-Nan ; XU, Xiao-Yan ; NIE, Xiao-Cui ; XUE, YANG ; MIAOYU ; XU, Hui-Mian ; LIU, Yun-Peng ; TAKANO, Yasuo ; ZHENG, Hua-Chuan
Link:	View record from PASCAL Archive
Zeitschrift:	Human pathology, Jg. 43 (2012), Heft 12, S. 2299-2307
Veröffentlichung:	New York, NY: Elsevier, 2012
Medientyp:	academicJournal
Umfang:	print, 19 ref
ISSN:	0046-8177 (print)
Schlagwort:	Medical oncology Cancérologie Medical laboratory techniques Techniques de laboratoire médical General medicine general surgery Médecine et chirurgie générales Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Gastroenterologie. Foie. Pancreas. Abdomen Gastroenterology. Liver. Pancreas. Abdomen Estomac. Duodénum. Intestin grêle. Côlon. Rectum. Anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumeurs Tumors Techniques d'exploration et de diagnostic (generalites) Investigative techniques, diagnostic techniques (general aspects) Anatomopathologie. Exploration cytologique. Biochimie. Spectrométries. Méthodes cliniques et paracliniques diverses Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Cancer Cáncer Pathologie de l'appareil digestif Digestive diseases Aparato digestivo patología Pathologie de l'estomac Gastric disease Estómago patología Tumeur maligne Malignant tumor Tumor maligno Anatomopathologie Anatomic pathology Anatomía patológica Cancer de l'estomac Stomach cancer Cáncer del estómago Carcinome de l'estomac Stomach carcinoma Carcinoma del estómago Chimiokine CXC CXC chemokine Quimioquina CXC Cytokine Citoquina Histopathologie Histopathology Histopatología Ligand Ligando Récepteur chimiokine Chemokine receptor Receptor quimioquina CXCL16 CXCR6 Gastric carcinoma
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China ; Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China ; Department of Internal Oncology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China ; Clinical Research Institute, Kanagawa Cancer Center, Yokohama 241-0815, Japan Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Gastroenterology. Liver. Pancreas. Abdomen ; Scanning and diagnostic techniques (generalities)

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Role and clinicopathologic significance of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 expression in gastric carcinomas