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Purpose: Lamotrigine (LTG) is an effective clinical treatment for epilepsy associated with absence seizures. However, the impact of LTG administration in studies employing various animal models of epilepsy remains controversial. This study aimed to clarify the outcomes of LTG treatment on absence seizures and comorbid anxiety and depression disorders in Long-Evans rats with spontaneous spike-wave discharges (SWDs). Methods: LTG (10 mg/kg) or water vehicle was chronically administered perorally to Long-Evans rats (twice daily for 35 days). Cortical activities were recorded to assess the presence of SWDs. Five behavioral tests, including the open field (OF), elevated plus maze (EPM), sucrose consumption (SC), sucrose preference, and forced swimming (FS) tests, were performed after LTG/ vehicle treatment. The behavioral indexes of these tests were designed to assess anxiety (OF and EPM tests), depression (SC and FS tests), and preference for hedonistic stimuli (sugar preference test). Key Findings: Total SWD duration, SWD number, and mean SWD duration were significantly decreased in rats that received 35-day LTG treatment compared with rats that received vehicle treatment. Rats with spontaneous SWDs versus rats with no SWDs showed significant levels of anxiety and depression in the OF, EPM, and SC tests. Rats with SWDs also showed longer immobility in the FS test. However, the LTG-treated group compared with the vehicle group presented with significantly lower manifestations of anxiety and depression in the OF, EPM, SC, and sucrose preference tests and shorter immobility in the FS test. Significance: The results of this study suggest that chronic LTG treatment can benefit patients with epilepsy via suppression of absence seizures and amelioration of comorbid anxiety and depression.

Titel:	Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy
Autor/in / Beteiligte Person:	HUANG, Hsin-Yi ; LEE, Hsiao-Wei ; CHEN, Shang-Der ; SHAW, Fu-Zen
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Epilepsia (Copenhagen), Jg. 53 (2012), Heft 11, S. 2005-2014
Veröffentlichung:	Malden, MA: Wiley-Blackwell, 2012
Medientyp:	academicJournal
Umfang:	print, 1 p
ISSN:	0013-9580 (print)
Schlagwort:	Neurology Neurologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Neuropharmacologie Neuropharmacology Anticonvulsivants. Antiépileptiques. Antiparkinsoniens Anticonvulsants. Antiepileptics. Antiparkinson agents Système nerveux (sémiologie, syndromes) Nervous system (semeiology, syndromes) Syndromes encéphaliques généraux: céphalées, douleurs de la face, syncopes, épilepsie, hypertension intracrânienne, oedème cérébral. Infirmité motrice cérébrale Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Affect affectivité Affect affectivity Afecto afectividad Dérivé de la triazine Triazine derivatives Triazina derivado Mammalia Pathologie de l'encéphale Cerebral disorder Encéfalo patología Pathologie du système nerveux central Central nervous system disease Sistema nervosio central patología Rodentia Trouble de l'humeur Mood disorder Trastorno humor Trouble neurologique Neurological disorder Trastorno neurológico Vertebrata Angoisse anxiété Anxiety Angustia ansiedad Animal Anticonvulsivant Anticonvulsant Anticonvulsivante Convulsion Convulsión Epilepsie Epilepsy Epilepsia Etat dépressif Depression Estado depresivo Lamotrigine Lamotrigina Modèle animal Animal model Modelo animal Pathologie du système nerveux Nervous system diseases Sistema nervioso patología Pointe onde Spike wave Espiga onda Rat Rata Trouble psychiatrique Mental disorder Trastorno psiquiátrico Absence epilepsy Long-Evans rat Spike-wave discharge
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Institute of Cognitive Science, National Cheng Kung University, Tainan, Tawain, Province of China ; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Tawain, Province of China ; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Tawain, Province of China ; Department of Psychology, National Cheng Kung University, Tainan, Tawain, Province of China Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Neurology ; Pharmacological treatments ; Psychopathology. Psychiatry. Clinical psychology

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Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy