Vitamin D Status and Coronary Flow Reserve Measured by Positron Emission Tomography: A Co-Twin Control Study
In: The Journal of clinical endocrinology and metabolism, Jg. 98 (2013), Heft 1, S. 389-397
Online
academicJournal
- print, 54 ref
Zugriff:
Context: Vitamin D insufficiency is associated with increased cardiovascular events in the general population. Additionally, low serum 25-hydroxyvitamin D [25(OH)D] is associated with endothelial dysfunction and arterial stiffness. However, little is known about the association between serum 25(OH)D level and myocardial blood flow. Objective: Our objective was to examine the association between serum 25(OH)D levels and coronary flow reserve (CFR) measured by 13N-positron emission tomography in asymptomatic middle-aged male twins. Design: The Emory Twin Study is a cross-sectional study of soldiers from the Vietnam Era Registry. Setting: The study was conducted at the General Clinical Research Center, Emory University, Atlanta, GA. Participants: A total of 368 middle-aged male twins were enrolled for the study. Serum 25(OH)D levels were measured in all subjects and classified as vitamin D insufficiency [25(OH)D <30 ng/ml] or sufficiency [25(OH)D ≥30 ng/ml]. Positron emission tomography with [13N]ammonia was used to evaluate myocardial blood flow at rest and after adenosine stress. CFR was measured as the ratio of maximum to rest myocardial blood flow. Main Outcome Measure: Primary outcome was CFR measurement. Results: Mean overall serum 25(OH)D concentration was 37.0 ± 21.4 ng/ml; 167 twins (45%) were vitamin D insufficient. CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. An abnormal CFR (CFR <2) was more prevalent in subjects with vitamin D insufficiency than with vitamin D sufficiency (31 vs. 20%; P = 0.03). In addition, in vitamin D status-discordant twin pairs, CFR was significantly lower in the vitamin D-insufficient twin than in the vitamin D-sufficient co-twin (2.35 vs. 2.58; P = 0.037). Conclusion: Vitamin D insufficiency is associated with lower CFR in men. This association may help explain some of the increased cardiovascular risk reported in individuals with vitamin D insufficiency. I.
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Vitamin D Status and Coronary Flow Reserve Measured by Positron Emission Tomography: A Co-Twin Control Study
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Autor/in / Beteiligte Person: | KAROHL, Cristina ; VACCARINO, Viola ; VELEDAR, Emir ; GOLDBERG, Jack ; TANGPRICHA, Vin ; BELLASI, Antonio ; RAGGI, Paolo |
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Zeitschrift: | The Journal of clinical endocrinology and metabolism, Jg. 98 (2013), Heft 1, S. 389-397 |
Veröffentlichung: | Bethesda, MD: Endocrine Society, 2013 |
Medientyp: | academicJournal |
Umfang: | print, 54 ref |
ISSN: | 0021-972X (print) |
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