Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma
In: International journal of hematology, Jg. 97 (2013), Heft 2, S. 232-239
Online
academicJournal
- print, 22 ref
Zugriff:
Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six patients with stage II DLBCL, diagnosed from 2000―2007, were categorized into localized (n = 55, 64 %) and disseminated groups (n = 31, 36 %) based on tumor extent at time of diagnosis. Treatment modalities, chemotherapy regimen and number of chemotherapy cycles were the same between groups. With a median follow-up of 7.6 years (range 2.1―12.1 years), overall 5-year event-free survival (EFS) and overall survival (OS) were 70.6 and 76.5 %, respectively. EFS (P = 1.00) and OS (P = 0.20) did not differ between the two groups. Older age (>60 years) was significantly associated with poor EFS (P = 0.01) and OS (P = 0.04). High-risk patients as rated by stage-modified international prognostic index (IPI) had inferior EFS (P = 0.04) and OS (P = 0.06) compared with the intermediate-risk group. These results indicate that tumor extent has no prognostic value in patients with early-stage DLBCL. Consistent with previous studies, age and stage-modified IPI were useful prognostic indices for these patients.
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Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma
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Autor/in / Beteiligte Person: | YOO, Changhoon ; DOK HYUN, YOON ; SUH, Cheolwon ; JEONG EUN, KIM ; JO, Jungmin ; SEONG JOON, PARK ; YOON, Shin-Kyo ; AHN, Yongchel ; KIM, Shin ; HUH, Jooryung ; DAE HO, LEE |
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Zeitschrift: | International journal of hematology, Jg. 97 (2013), Heft 2, S. 232-239 |
Veröffentlichung: | Heidelberg: Springer, 2013 |
Medientyp: | academicJournal |
Umfang: | print, 22 ref |
ISSN: | 0925-5710 (print) |
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