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Background: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake. Design: We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations of European descent. Macronutrients were assessed by using food-frequency questionnaires and analyzed as percentages of total energy consumption from total fat, protein, and carbohydrate. From the discovery GWA (n = 38,360), 35 independent loci associated with macronutrient intake at P < 5 × 10―6 were identified and taken forward to replication in 3 additional cohorts (n = 33,533) from the DietGen Consortium. For one locus, fat mass obesity-associated protein (FTO), cohorts with Illumina MetaboChip genotype data (n = 7724) provided additional replication data. Results: A variant in the chromosome 19 locus (rs838145) was associated with higher carbohydrate (β ± SE: 0.25 ± 0.04%; P = 1.68 × 10―8) and lower fat (β ± SE: ―0.21 ± 0.04%; P = 1.57 X 10―9) consumption. A candidate gene in this region, fibroblast growth factor 21 (FGF21), encodes a fibroblast growth factor involved in glucose and lipid metabolism. The variants in this locus were associated with circulating FGF21 protein concentrations (P < 0.05) but not mRNA concentrations in blood or brain. The body mass index (BMI)―increasing allele of the FTO variant (rsl421085) was associated with higher protein intake (β ± SE: 0.10 ± 0.02%; P = 9.96 × 10―10), independent of BMI (after adjustment for BMI, β ± SE: 0.08 ± 0.02%; P = 3.15 × 10―7). Conclusion: Our results indicate that variants in genes involved in nutrient metabolism and obesity are associated with macronutrient consumption in humans. Trials related to this study were registered at clinicaltrials.gov as NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetic and Environmental Determinants of Triglycerides), NCT01331512 (InCHIANTI Study), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).

Titel:	Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
Autor/in / Beteiligte Person:	TANAKA, Toshiko ; NGWA, Julius S ; MIKKILÄ, Vera ; RENSTROM, Frida ; SONESTEDT, Emily ; JING HUA, ZHAO ; CHU, Audrey Y ; LU, QI ; CHASMAN, Daniel I ; DE OLIVEIRA OTTO, Marcia C ; DHURANDHAR, Emily J ; FEITOSA, Mary F ; ROOIJ, Frank Ja Van ; JOHANSSON, Ingegerd ; KHAW, Kay-Tee ; LOHMAN, Kurt K ; MANICHAIKUL, Ani ; MCKEOWN, Nicola M ; MOZAFFARIAN, Dariush ; SINGLETON, Andrew ; STIRRUPS, Kathleen ; VIIKARI, Jorma ; ZHENG, YE ; ZILLIKENS, M. Carola ; BANDINELLI, Stefania ; BARROSO, Inês ; DELOUKAS, Panos ; FOROUHI, Nita G ; HOFMAN, Albert ; YONGMEI, LIU ; LYYTIKÄINEN, Leo-Pekka ; NORTH, Kari E ; DIMITRIOU, Maria ; HALLMANS, Goran ; WOJCZYNSKI, Mary K ; KÄHÖNEN, Mika ; LANGENBERG, Claudia ; ORDOVAS, Jose M ; UITTERLINDEN, André G ; HU, Frank B ; KALAFATI, Ioanna-Panagiota ; RAITAKARI, Olli ; FRANCO, Oscarh ; JOHNSON, Andrew ; EMILSSON, Valur ; FRAZIER-WOOD, Alexis C ; SCHRACK, Jennifera ; SEMBA, Richard D ; SISCOVICK, David S ; ARNETT, Donna K ; BORECKI, Ingrid B ; FRANKS, Paul W ; KRITCHEVSKY, Stephen B ; LEHTIMÄKI, Terho ; LOOS, Ruth Jf ; ORHO-MELANDER, Marju ; HOUSTON, Denise K ; KANONI, Stavroula ; LEMAITRE, Rozenn N ; LUAN, Jian'an
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	The American journal of clinical nutrition, Jg. 97 (2013), Heft 6, S. 1395-1402
Veröffentlichung:	Bethesda, MD: American Society for Nutrition, 2013
Medientyp:	academicJournal
Umfang:	print, 49 ref
ISSN:	0002-9165 (print)
Schlagwort:	Endocrinology Endocrinologie Nutrition, obesity, metabolic disorders Nutrition, obésité, maladies métaboliques Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Vertebres: anatomie et physiologie, organisme dans son ensemble ou etude de plusieurs organes ou systemes Vertebrates: anatomy and physiology, studies on body, several organs or systems Alimentation. Comportement alimentaire Feeding. Feeding behavior Génome Genome Genoma Macronutriment Macronutrient Macronutriente Variant génétique Genetic variant Variante genética
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States ; Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States ; Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland ; Department of Nutrition, Harvard School of Public Health, Boston, MA, United States ; Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden ; Department of Clinical Sciences, Lund University, Malmö, Sweden ; MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States ; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States ; Harvard Medical School, Boston, MA, United States ; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States ; Department of Epidemiology, Section on Statistical Genetics, and The Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States ; Department of Genetics, Washington University School of Medicine, St Louis, MO, United States ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands ; The Netherlands Genomics Initiativesponsored Netherlands Consortium for Healthy Aging, Leiden, Netherlands ; Department of Odontology, Umeå University, Umea, Sweden ; Departments of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands ; Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States ; Department of Nutritional Research, Umeå University, Umea, Sweden ; Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden ; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, United States ; Institute of Medical Science, Addenbrooke's Hospital, Cambridge, United Kingdom ; Department of Medicine, University of Washington, Seattle, WA, United States Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Vertebrates : anatomy and physiology, studies on body, several organs or systems

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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake