Einzeltreffer — DigiBib

Posttransplant patients are at risk of developing a potentially life-threatening posttransplantation lymphoproliferative disorder (PTLD), most often of diffuse large B cell lymphoma (DLBCL) morphology and associated with Epstein-Barr Virus (EBV) infection. The aim of this study was to characterize the clinicopathological and molecular-genetic characteristics of posttransplant DLBCL and to elucidate whether EBV(+) and EBV(―) posttransplant DLBCL are biologically different. We performed gene expression profiling studies on 48 DLBCL of which 33 arose posttransplantation (PT-DLBCL; 72% EBV+) and 15 in immunocompetent hosts (IC-DLBCL; none EBV+). Un-supervised hierarchical analysis showed clustering of samples related to EBV-status rather than immune status. Except for decreased T cell signaling these cases were inseparable from EBV(―) IC-DLBCL. In contrast, a viral response signature clearly segregated EBV(+) PT-DLBCL from EBV(―) PT-DLBCL and IC-DLBCL cases that were intermixed. The broad EBV latency profile (LMP1+/EBNA2+) was expressed in 59% of EBV(+) PT-DLBCL and associated with a more elaborate inflammatory response compared to intermediate latency (LMP1+/EBNA2―). Inference analysis revealed a role for innate and tolerogenic immune responses (including VSIG4 and ID01) in EBV(+) PT-DLBCL. In conclusion we can state that the EBV signature is the most determining factor in the pathogenesis of EBV(+) PT-DLBCL.

Titel:	Gene Expression Profiling Reveals Clear Differences Between EBV-Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders
Autor/in / Beteiligte Person:	MORSCIO, J ; DIERICKX, D ; DE WOLF-PEETERS, C ; SAGAERT, X ; TOUSSEYN, T ; FERREIRO, J. F ; HERREMAN, A ; VAN LOO, P ; BITTOUN, E ; VERHOEF, G ; MATTHYS, P ; COOLS, J ; WLODARSKA, I
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	American journal of transplantation (Print), Jg. 13 (2013), Heft 5, S. 1305-1316
Veröffentlichung:	Hoboken, NJ: Wiley, 2013
Medientyp:	academicJournal
Umfang:	print, 27 ref
ISSN:	1600-6135 (print)
Schlagwort:	Graft, transplantation Greffe, transplantation Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pathologie infectieuse Infectious diseases Viroses Viral diseases Hemopathies Hematologic and hematopoietic diseases Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Cancer Cáncer Chirurgie Surgery Cirugía Gammaherpesvirinae Greffe Graft Injerto Herpesviridae Hémopathie maligne Malignant hemopathy Hemopatía maligna Immunopathologie Immunopathology Inmunopatología Infection Infección Lymphome non hodgkinien Non Hodgkin lymphoma Linfoma no Hodgkin Virus Carcinogenèse Carcinogenesis Carcinogénesis Etude comparative Comparative study Estudio comparativo Homotransplantation Homotrasplante Immunodéficit Immune deficiency Inmunodeficiencia Lymphome diffus à grandes cellules B Diffuse large B cell lymphoma Linfoma difuso de grandes células B Organe Organ Organo Syndrome lymphoprolifératif posttransplantation Posttransplant lymphoproliferative disorder Síndrome linfoproliferativo postrasplante Syndrome lymphoprolifératif Lymphoproliferative syndrome Linfoproliferativo síndrome Traitement Treatment Tratamiento Transplantation Trasplantación Tumeur maligne Malignant tumor Tumor maligno Virose Viral disease Virosis Virus Epstein Barr Epstein Barr virus Profil d'expression génique Gene expression profile Perfil de expresión genética ABC DLBCL EBV GCB IC-DLBCL PT-DLBCL gene expression profiling immunodeficiency lymphoid neoplasia lymphomagenesis microarray monomorphic PTLD organ transplantation posttransplantation lymphoproliferative disorder
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium ; Department of Hematology, University Hospitals KU Leuven, Leuven, Belgium ; Department of Pathology; University Hospitals KU Leuven, Leuven, Belgium ; Department of Human Genetics, KU Leuven, Laboratory for Genetics of Malignant Disorders, Leuven, Belgium ; Center for the Biology of Disease, VIB, Leuven, Belgium ; Center for Human Genetics, KU Leuven, Leuven, Belgium ; REGA Institute, KU Leuven, Leuven, Belgium Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Blood diseases ; Infectious pathology ; Surgery (generalities). Transplants, organs and tissues grafting. Graft pathologies

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Gene Expression Profiling Reveals Clear Differences Between EBV-Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders