Lipoprotein metabolism during and after a 6-h infusion of MCT/LCT vs LCT emulsion in man
In: Clinical nutrition (Edinburgh), Jg. 16 (1997), Heft 3, S. 119-123
academicJournal
- print, 15 ref
Zugriff:
We studied, in man, the intravascular metabolism of two lipid emulsions differing in their triglyceride (TG) fatty acid pattern. One emulsion was composed exclusively of soy bean long-chain triglycerides (LCT), the other of a mixture containing a (1:1, wt:wt) ratio of medium-chain triglycerides (MCT) and LCT (MCT/LCT). Both emulsions contained 10% TG and 1.2% of the same egg yolk phospholipid emulsifier. Six healthy volunteers received both emulsions, in random order, at a rate of 0.2 g TG/kg.h for 6 h. An interval of 2 weeks separated the tests. Although the MCT/LCT emulsion provided 39% more TG molecules than the pure LCT emulsion, plasma TG increased to similar levels, indicating a faster elimination of MCT/LCT. The rise of plasma non esterified fatty acids was greater with MCT/LCT (P< 0.001). LDL-TG enrichment was higher with MCT/LCT (P < 0.025) while net transfer of TG to HDL was similar with both emulsions. Cholesteryl ester (CE) enrichment in the 'VLDL' fraction (largely composed of emulsion particles) was markedly less during MCT/LCT than LCT infusions (P < 0.01). CE enrichment of the 'VLDL' fraction persisted up to 6 h after cessation of both lipid infusions. In conclusion, TG from MCT/LCT emulsion appear to be eliminated faster than LCT during an in vivo infusion in man. In accordance with our previous in vitro data, MCT/LCT infusion was associated with a higher transfer of TG to LDL and in a reverse manner, with a lesser acquisition of CE by emulsion particles as compared to LCT infusion.
Titel: |
Lipoprotein metabolism during and after a 6-h infusion of MCT/LCT vs LCT emulsion in man
|
---|---|
Autor/in / Beteiligte Person: | RICHELLE, M ; DECKELBAUM, R. J ; VANWEYENBERG, V ; CARPENTIER, Y. A |
Link: | |
Zeitschrift: | Clinical nutrition (Edinburgh), Jg. 16 (1997), Heft 3, S. 119-123 |
Veröffentlichung: | Kidlington: Elsevier, 1997 |
Medientyp: | academicJournal |
Umfang: | print, 15 ref |
ISSN: | 0261-5614 (print) |
Schlagwort: |
|
Sonstiges: |
|