Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
In: European journal of clinical pharmacology, Jg. 69 (2013), Heft 8, S. 1589-1597
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academicJournal
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Zugriff:
Objective Few studies have investigated potentially inappropriate medication (PIM) use in patients with Alzheimer's disease (AD). The aim of our study was to assess the prevalence of PIM in community-dwelling patients diagnosed with mild-to-moderate AD and identify the clinical factors associated with PIM prescriptions. Methods REAL.FR is a 4-year, prospective, multicenter French cohort of AD patients recruited in centers of expertise. We analyzed patient baseline data at entry into the study. PIMs were assessed using the Laroche list. A multivariate logistic regression was conducted to assess factors associated with PIMs. Results A total of 684 AD patients were enrolled in the study [mean age 77.9±6.8 years, 486 (71.0 %) females]. According to the Laroche list, 46.8 % [95 % confidence interval (CI) 43.0―50.5 %] of the patients had at least one PIM. Cerebral vasodilators were the most widely used class of PIM, accounting for 24.0 % (95 % CI 20.9―27.3 %) of all prescriptions, followed by atropinic drugs (17.0 %, 95 % CI 14.1― 19.8 %) and long half-life benzodiazepines (8.5 %, 95 % CI 6.4―10.6 %). Atropinic drugs were associated with cholinesterase inhibitors in 16 % of patients. In the multivariate analysis, only two factors, namely, female gender [odds ratio (OR) 1.5, 95 % CI 1.1―2.2] and polypharmacy (≥5 drugs; OR3.6, 95 % CI 2.6―4.5) were associated with prescriptions for PIMs. Conclusions These results reveal that approximately one out of two community-dwelling patients with mild-to-moderate AD treated by AD specialists use PIMs. They also indicate that the characteristics of the disease and the pharmacodynamic/pharmacokinetic profile of the drugs prescribed are not sufficiently taken into account by physicians when prescribing for AD patients.
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Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
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Autor/in / Beteiligte Person: | MONTASTRUC, François ; GARDETTE, Virginie ; CANTET, Christelle ; PIAU, Antoine ; LAPEYRE-MESTRE, Maryse ; VELLAS, Bruno ; MONTASTRUC, Jean-Louis ; ANDRIEU, Sandrine ; Group, REAL.FR |
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Zeitschrift: | European journal of clinical pharmacology, Jg. 69 (2013), Heft 8, S. 1589-1597 |
Veröffentlichung: | Heidelberg: Springer, 2013 |
Medientyp: | academicJournal |
Umfang: | print, 44 ref |
ISSN: | 0031-6970 (print) |
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