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Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case―control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case―control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season-standardized 25(OH)D levels and the risk of breast cancer (ORQ4―Q1 [95% CI]: 1.07 [0.85―1.36], Ptrend = 0.67). Moreover, 25(OH)D levels were not related to the risks of estrogen receptor positive tumors (ORQ4―Q1 [95% CI]: 0.97 [0.67―1.38], Ptrend = 0.90) and estrogen receptor negative tumors (ORQ4―Q1 [95% CI]: 0.97 [0.66―1.42], Ptrend = 0.98). In hormone replacement therapy (HRT) users, 25(OH)D was significantly inversely associated with incident breast cancer (ORlog2 [95% CI]: 0.62 [0.42―0.90], p = 0.01), whereas no significant association was found in HRT nonusers (ORlog2 [95% CI]: 1.14 [0.80―1.62], p = 0.48). Further, a nonsignificant inverse association was found in women with body mass indices (BMI) < 25 kg/m2 (ORlog2 [95% CI]: 0.83 [0.67―1.03], p = 0.09), as opposed to a borderline significant positive association in women with BMI > 25 kg/m2 (ORlog2 [95% CI]: 1.30 [1.0―1.69], p = 0.05). Overall, prediagnostic levels of circulating 25(OH)D were not related to the risk of breast cancer in the EPIC study. This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer.

Titel:	Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition: A nested case-control study
Autor/in / Beteiligte Person:	KÜHN, Tilman ; KAAKS, Rudolf ; CHANG-CLAUDE, Jenny ; LUKANOVA, Annekatrin ; BUIJSSE, Brian ; BOEING, Heiner ; TRICHOPOULOU, Antonia ; LAGIOU, Pagona ; BAMIA, Christina ; MASALA, Giovanna ; KROGH, Vittorio ; SACERDOTE, Carlotta ; BECKER, Susen ; TUMINO, Rosario ; MATTIELLO, Amalia ; BUCKLAND, Genevieve ; SANCHEZ, María-José ; MENENDEZ, Virginia ; CHIRLAQUE, María-Dolores ; BARRICARTE, Aurelio ; BAS BUENO-DE-MESQUITA, H ; VAN DUIJNHOVEN, Fränzel J. B ; VAN GILS, Carla H ; EOMOIS, Piia-Piret ; BAKKER, Marije F ; WEIDERPASS, Elisabete ; SKEIE, Guri ; BRUSTAD, Magritt ; ANDERSSON, Anne ; SUND, Malin ; WAREHAM, Nick ; KAY TEE, KHAW ; TRAVIS, Ruth C ; SCHMIDT, Julie A ; CLAVEL-CHAPELON, Françoise ; RINALDI, Sabina ; ROMIEU, Isabelle ; GALLO, Valentina ; MURPHY, Neil ; RIBOLI, Elio ; LINSEISEN, Jakob ; KVASKOFF, Marina ; DOSSUS, Laure ; TJONNELAND, Anne ; OLSEN, Anja ; OVERVAD, Kim
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	International journal of cancer (Print), Jg. 133 (2013), Heft 7, S. 1689-1700
Veröffentlichung:	Hoboken, NJ: Wiley-Blackwell, 2013
Medientyp:	academicJournal
Umfang:	print, 50 ref
ISSN:	0020-7136 (print)
Schlagwort:	Europe Europa Medical oncology Cancérologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Tumeurs Tumors Tumeurs multiples. Tumeurs solides. Tumeurs chez l'enfant (généralités) Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Gynecologie. Andrologie. Obstetrique Gynecology. Andrology. Obstetrics Pathologie de la glande mammaire Mammary gland diseases Cancer Cáncer Hormone ovarienne Ovarian hormone Hormona ovárica Hormone stéroïde sexuelle Sex steroid hormone Hormona esteroide sexual Glándula mamaria patología Pathologie du sein Breast disease Seno patología Santé publique Public health Salud pública Tumeur maligne Malignant tumor Tumor maligno Calcitriol Cancer du sein Breast cancer Cáncer del pecho Cancerology Cancerología Cholécalciférol(25-hydroxy) Cholecalciferol(25-hydroxy) Colecalciferol(25-hidroxi) Etude cas témoin Case control study Estudio caso control Facteur risque Risk factor Factor riesgo Homme Human Hombre Plasma sanguin Blood plasma Plasma sanguíneo Prospective Prospectiva Récepteur hormonal Hormonal receptor Receptor hormonal Récepteur oestrogène Estrogen receptor Receptor estrógeno Vitamine D Vitamin D Vitamina D 25-hydroxyvitamin D breast cancer estrogen receptor status prospective study vitamin D Subject Geographic: Europe Europa
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany ; Department of Epidemiology, German Institute of Human Nutrition (DlfE) Potsdam-Rehbrücke, Nuthetal, Germany ; WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece ; Hellenic Health Foundation, Athens, Greece ; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States ; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy ; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy ; Center for Cancer Prevention (CPO-Piemonte), Torino, Italy ; Molecular and Genetic Epidemiology, Human Genetic Foundation (HuGeF), Torino, Italy ; Institute of Laboratory Medicine, University Hospital Leipzig, Leipzig, Germany ; Cancer Registry and Histopathology Unit, Civile - M.P.Arezzo Hospital ASP, Ragusa, Italy ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain ; Andalusian School of Public Health, Granada, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Spain ; Public Health Directorate Asturias, Oviedo, Spain ; Department of Epidemiology, Regional Health Council, Murcia, Spain ; Public Health Institute of Navarra, Pamplona, Spain ; National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands ; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands ; Division of Human Nutrition, Wageningen University, Wageningen, Netherlands ; INSERM, Centre for Research in Epidemiology and Population Health, U1018, Institut Gustave Roussy, Villejuif, France ; Paris South University, UMRS 1018, Villejuif, France ; Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark ; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Gynecology. Andrology. Obstetrics ; Tumours

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Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition: A nested case-control study