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OBJECTIVE—Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS—Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and laboratory values, blood pressure, and IMT were measured. ANCOVA was used to assess differences controlling for demographic risk factors, cardiovascular risk factors, and HbA1c. RESULTS—Subjects were 18.9 ± 3.3 years old (50% male, 82.7% non-Hispanic white). Youth with type 1 diabetes had thicker bulb IMT, which remained significantly different after adjustment for demographics and cardiovascular risk factors. Age, sex, adiposity, and systolic blood pressure were consistent significant determinants of IMT. Adjustment for HbA1c eliminated the difference, suggesting the difference was attributable to poor glycemic control. CONCLUSIONS—Carotid IMT may be increased in youth with type 1 diabetes at high risk for cardiovascular disease. Better control of diabetes may be essential in preventing progression of atherosclerosis.

Titel:	Effect of Type 1 Diabetes on Carotid Structure and Function in Adolescents and Young Adults: The SEARCH CVD study
Autor/in / Beteiligte Person:	URBINA, Elaine M ; DABELEA, Dana ; D'AGOSTINO, Ralph B ; SHAH, Amy S ; DOLAN, Lawrence M ; HAMMAN, Richard F ; DANIELS, Stephen R ; MARCOVINA, Santica ; WADWA, R. Paul
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Diabetes care, Jg. 36 (2013), Heft 9, S. 2597-2599
Veröffentlichung:	Alexandria, VA: American Diabetes Association, 2013
Medientyp:	academicJournal
Umfang:	print, 16 ref
ISSN:	0149-5992 (print)
Schlagwort:	Endocrinology Endocrinologie Nutrition, obesity, metabolic disorders Nutrition, obésité, maladies métaboliques Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Endocrinopathies Pancréas endocrine. Cellules apud (pathologie) Endocrine pancreas. Apud cells (diseases) Diabète. Anomalie tolérance glucose Diabetes. Impaired glucose tolerance Etiopathogénie. Dépistage. Explorations. Résistance tissu cible Etiopathogenesis. Screening. Investigations. Target tissue resistance Maladies metaboliques Metabolic diseases Sante publique. Hygiene-medecine du travail Public health. Hygiene-occupational medicine Santé publique. Hygiène Public health. Hygiene Divers Miscellaneous Appareil circulatoire Circulatory system Aparato circulatorio Artère Artery Arteria Endocrinopathie Endocrinopathy Endocrinopatía Homme Human Hombre Immunopathologie Immunopathology Inmunopatología Vaisseau sanguin Blood vessel Vaso sanguíneo Adolescent Adolescente Adulte jeune Young adult Adulto joven Carotide Carotid Carótida Diabète de type 1 Type 1 diabetes Diabetes de tipo 1 Endocrinología Maladie autoimmune Autoimmune disease Enfermedad autoinmune Maladie métabolique Metabolismo patología Nutrition Nutrición Pathologie de l'appareil circulatoire Cardiovascular disease Aparato circulatorio patología
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Cincinnati Children's Hospital and University of Cincinnati, Department of Pediatrics, Cincinnati, Ohio, United States ; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, Aurora, Colorado, United States ; Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States ; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States ; Northwest Lipid Research Laboratories, University of Washington, Seattle, Washington, United States Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Endocrinopathies ; Metabolic diseases ; Public health. Hygiene-occupational medicine. Information processing

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Effect of Type 1 Diabetes on Carotid Structure and Function in Adolescents and Young Adults: The SEARCH CVD study