Cerebral white matter blood flow and energy metabolism in multiple sclerosis
In: Multiple sclerosis, Jg. 19 (2013), Heft 10, S. 1282-1289
Online
academicJournal
- print, 34 ref
Zugriff:
Background: Cerebral blood flow (CBF) is reduced in normal-appearing white matter (NAWM) of subjects with multiple sclerosis (MS), but the underlying mechanism is unknown. Objective: The objective of this article is to assess the relationship between reduced NAWM CBF and both axonal mitochondrial metabolism and astrocytic phosphocreatine (PCr) metabolism. Methods: Ten healthy controls and 25 MS subjects were studied with 3 Tesla magnetic resonance imaging. CBF was measured using pseudo-continuous arterial spin labeling. N-acetylaspartate/creatine (NAA/Cr) ratios (axonal mitochondrial metabolism) were obtained using 1H-MR spectroscopy and PCr/β-ATP ratios using 31P-MR spectroscopy. In centrum semiovale NAWM, we assessed correlations between CBF and both NAA/Cr and PCr/β-ATP ratios. Results: Subjects with MS had a widespread reduction in CBF of NAWM (centrum semiovale, periventricular, frontal and occipital), and gray matter (frontoparietal cortex and thalamus). Compared to controls, NAA/Cr in NAWM of the centrum semiovale of MS subjects was decreased, whereas PCr/β-ATP was increased. We found no correlations between CBF and PCr/β-ATP. CBF and NAA/Cr correlated in controls (p = 0.02), but not in MS subjects (p = 0.68). Conclusions: Our results suggest that in MS patients there is no relationship between reduced CBF in NAWM and impaired axonal mitochondrial metabolism or astrocytic PCr metabolism.
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Cerebral white matter blood flow and energy metabolism in multiple sclerosis
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Autor/in / Beteiligte Person: | STEEN, Christel ; D'HAESELEER, Miguel ; HOOGDUIN, Johannes M ; FIERENS, Yves ; CAMBRON, Melissa ; MOSTERT, Jop P ; HEERSEMA, Dorothea J ; KOCH, Marcus W ; DE KEYSER, Jacques |
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Zeitschrift: | Multiple sclerosis, Jg. 19 (2013), Heft 10, S. 1282-1289 |
Veröffentlichung: | London: Sage Publications, 2013 |
Medientyp: | academicJournal |
Umfang: | print, 34 ref |
ISSN: | 1352-4585 (print) |
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