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OBJECTIVE: Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids. DESIGN AND METHODS: We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42000) and twelve SNPs in African Americans (N up to 5800). RESULTS: After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m―2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P<0.0001). Other fatty acids were not associated with outcomes. The association of SFA with outcomes varied by genotype at rs2306692 (genotyped in four studies of whites), where the magnitude of the association of SFA intake with each outcome was greater per additional copy of the T allele: 0.107 kg m―2 greater for BMI (interaction P=0.0001), 0.267 cm for waist (interaction P=0.001) and 0.21 cm for hip (interaction P=0.001). No other significant interactions were observed. CONCLUSION: Dietary SFA and LRP1 genotype may interactively influence anthropometric traits. Further exploration of this, and other diet x genotype interactions, may improve understanding of interindividual variability in the relationships of dietary factors with anthropometric traits.

Titel:	Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies
Autor/in / Beteiligte Person:	SMITH, C. E ; NGWA, J ; YE, Z ; BANDINELLI, S ; FRAZIER-WOOD, A. C ; HOUSTON, D. K ; HU, F ; LANGENBERG, C ; MCKEOWN, N. M ; MOZAFFARIAN, D ; NORTH, K. E ; VIIKARI, J ; TANAKA, T ; ZILLIKENS, M. C ; DJOUSSE, L ; HOFMAN, A ; KÄHÖNEN, M ; KABAGAMBE, E. K ; LOOS, R. J. F ; SAYLOR, G. B ; FOROUHI, N. G ; LIU, Y ; MUKAMAL, K. J ; QI, Q ; CHEN, Y-D. I ; TSAI, M. Y ; UITTERLINDEN, A. G ; RAITAKARI, O ; VAN DUIJN, C. M ; ARNETT, D. K ; BORECKI, I. B ; CUPPLES, L. A ; FERRUCCI, L ; KRITCHEVSKY, S. B ; WOJCZYNSKI, M. K ; LEHTIMÄKI, T ; LU, QI ; ROTTER, J. I ; SISCOVICK, D. S ; WAREHAM, N. J ; WITTEMAN, J. C. M ; ORDOVAS, J. M ; NETTLETON, J. A ; LEMAITRE, R. N ; ANDERSON, J. S ; MANICHAIKUL, A ; MIKKILÄ, V ; VAN ROOIJ, Fja
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	International journal of obesity, Jg. 37 (2013), Heft 9, S. 1211-1220
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2013
Medientyp:	academicJournal
Umfang:	print, 39 ref
ISSN:	0307-0565 (print)
Schlagwort:	Europe Europa Nutrition, obesity, metabolic disorders Nutrition, obésité, maladies métaboliques Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Maladies metaboliques Metabolic diseases Obésité Obesity Sante publique. Hygiene-medecine du travail Public health. Hygiene-occupational medicine Santé publique. Hygiène Public health. Hygiene Divers Miscellaneous Lipide Lipids Lípido Pratique basée sur des preuves Evidence-based practice Práctica basada en la evidencia Trouble de la nutrition Nutrition disorder Trastorno nutricíon Acide gras saturé Saturated fatty acid Acido graso saturado Acide gras Fatty acids Acido graso Afro Américain African American Afroamericano Aliment Food Alimento Alimentation Feeding Alimentación Etat nutritionnel Nutritional status Estado nutricional Européen European Europeo Homme Human Hombre Interaction génique Gene interaction Interacción génica Lipoprotéine LDL Lipoprotein LDL Lipoproteína LDL Médecine factuelle Evidence-based medicine Medicina basada en pruebas Métaanalyse Metaanalysis Meta-análisis Protéine récepteur Receptor protein Proteína receptor Régime alimentaire Diet Régimen alimentario Santé publique Public health Salud pública Variant Variante SNPs gene―diet interactions low-density lipoprotein receptor-related protein 1 saturated fatty acids Subject Geographic: Europe Europa
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States ; Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States ; MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom ; Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy ; Department of Epidemiology, Section on Statistical Genetics, and The Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States ; Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, United States ; Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States ; Department of Nutrition, Harvard School of Public Health, Boston, MA, United States ; Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, United States ; Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States ; Department of Epidemiology and Carolina Center for Genome Sciences; University of North Carolina, Chapel Hill, NC, United States ; Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland ; Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States ; The Netherlands Genomics Initiative―sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden, Netherlands ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Boston VA Healthcare System, Boston, MA, United States ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands ; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland ; Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston Salem, NC, United States ; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, United States ; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States ; Department of Medicine, University of Washington, Seattle, WA, United States ; Center for Public Health Genomics and Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, United States ; Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Metabolic diseases ; Public health. Hygiene-occupational medicine. Information processing

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Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies