N-Glycosylation of Plant-produced Recombinant Proteins
In: From Medicinal Plants to Medicines in Plants: Plant Factories for the Production of Valuable Pharmaceuticals, Jg. 19 (2013), Heft 31, S. 5503-5512
academicJournal
- print, 120 ref
Zugriff:
Plants are gaining increasingly acceptance as a production platform for recombinant proteins. One reason for this is their ability to carry out posttranslational protein modifications in a similar if not identical way as mammalian cells. The capability of plants to carry out human-like complex glycosylation is well known. Moreover, the targeted manipulation of the plant N-glycosylation pathway allows the production of proteins carrying largely homogeneous, human-type oligosaccharides. These outstanding results have placed plants in a favourable position compared to other eukaryotic expression systems. This review provides a comprehensive summary of the N-glycosylation of plant-produced recombinant proteins, the possible impact of plant-specific N-glycans on the human immune system, and recent advances in engineering the plant N-glycosylation pathway towards the synthesis of (complex) human-type glycan structures, highlighting challenges and achievements in the application of these powerful technologies.
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N-Glycosylation of Plant-produced Recombinant Proteins
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Autor/in / Beteiligte Person: | BOSCH, Dirk ; CASTILHO, Alexandra ; LOOS, Andreas ; SCHOTS, Arjen ; STEINKELLNER, Herta |
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Zeitschrift: | From Medicinal Plants to Medicines in Plants: Plant Factories for the Production of Valuable Pharmaceuticals, Jg. 19 (2013), Heft 31, S. 5503-5512 |
Veröffentlichung: | Sharjah: Bentham, 2013 |
Medientyp: | academicJournal |
Umfang: | print, 120 ref |
ISSN: | 1381-6128 (print) |
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