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Preemptive therapy at CMV reactivation has diminished post-transplant CMV mortality. Furthermore, recent studies suggest a favorable 'virus-versus-leukemia' effect from reactivating CMV, reducing relapse of AML after SCT. We studied the relationship of CMV reactivation with leukemic relapse in 110 patients with CML receiving HLA-identical sibling SCT between 1993 and 2008. Of these, 79 (72%) were in chronic phase, 5 in second chronic phase, 17 in accelerated phase and 9 in blast phase. A total of 97 patients (88%) received a myeloablative conditioning regimen, 97 received 4-log ex vivo T cell-depleted grafts and 13 received T-replete grafts. CMV reactivation before day 100 was observed in 72 patients (65.5%). At a median follow-up of 6.2 years, CMV reactivation < day 100 as a time-dependent covariate was an independent factor associated with decreased relapse. We conclude that CMV reactivation may contribute to a beneficial GVL effect in CML transplant recipients.

Titel:	CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML
Autor/in / Beteiligte Person:	ITO, S ; POPHALI, P ; WU, C.O ; KOKLANARIS, E. K ; SUPERATA, J ; FAHLE, G. A ; CHILDS, R ; BATTIWALLA, M ; BARRETT, A. J
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Bone marrow transplantation (Basingstoke), Jg. 48 (2013), Heft 10, S. 1313-1316
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2013
Medientyp:	academicJournal
Umfang:	print, 26 ref
ISSN:	0268-3369 (print)
Schlagwort:	Medical oncology Cancérologie Graft, transplantation Greffe, transplantation Hematology Hématologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Hemopathies Hematologic and hematopoietic diseases Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Anesthesie. Reanimation. Transfusion. Therapie cellulaire et therapie genique Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Transfusions. Complications. Accidents transfusionnels. Thérapie cellulaire et thérapie génique Transfusions. Complications. Transfusion reactions. Cell and gene therapy Greffes de moelle osseuse, cellules souches. Réaction greffon contre l'hôte Bone marrow, stem cells transplantation. Graft versus host reaction Betaherpesvirinae Cancer Cáncer Herpesviridae Hémopathie maligne Malignant hemopathy Hemopatía maligna Syndrome myéloprolifératif Myeloproliferative syndrome Mieloproliferativo síndrome Virus Cellule hématopoïétique Hematopoietic cell Célula hematopoyética Cellule souche Stem cell Célula primitiva Cytomegalovirus Epidémiologie Epidemiology Epidemiología Homogreffe Homograft Homoinjerto Hematología Incidence Incidencia Leucémie myéloïde chronique Chronic myelogenous leukemia Leucemia mieloidea crónica Réactivation Reactivation Reactivación Récidive Relapse Recaida Allogreffe de cellules souches hématopoïétiques Allogeneic hematopoietic stem cell transplantation Aoinjerto de células precursoras hematopoyéticas Greffe de cellules souches hématopoïétiques Hematopoietic stem cell transplantation Injerto de célula primitiva hematopoyética CML CMV reactivation HSCT relapse
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States ; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States ; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy ; Blood diseases

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CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML