Einzeltreffer — DigiBib

Mantle cell lymphoma (MCL) is a B-cell neoplasm with an aggressive clinical behavior characterized by the t(11;14)(q13;q32) and cyclin D1 overexpression. To clarify the potential contribution of altered DNA methylation in the development and/or progression of MCL, we performed genome-wide methylation profiling of a large cohort of primary MCL tumors (n = 132), MCL cell lines (n = 6) and normal lymphoid tissue samples (n = 31), using the Infinium HumanMethylation27 BeadChip. DNA methylation was compared to gene expression, chromosomal alterations and clinicopathological parameters. Primary MCL displayed a heterogeneous methylation pattern dominated by DNA hypomethylation when compared to normal lymphoid samples. A total of 454 hypermethylated and 875 hypomethylated genes were identified as differentially methylated in at least 10% of primary MCL. Annotation analysis of hypermethylated genes recognized WNT pathway inhibitors and several tumor suppressor genes as frequently methylated, and a substantial fraction of these genes (22%) showed a significant downregulation of their transcriptional levels. Furthermore, we identified a subset of tumors with extensive CpG methylation that had an increased proliferation signature, higher number of chromosomal alterations and poor prognosis. Our results suggest that a subset of MCL displays a dysregulation of DNA methylation characterized by the accumulation of CpG hypermethylation highly associated with increased proliferation that may influence the clinical behavior of the tumors.

Titel:	Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features
Autor/in / Beteiligte Person:	ENJUANES, Anna ; ALBERO, Robert ; RIMSZA, Lisa ; BRAZIEL, Rita M ; DELABIE, Jan ; COOK, James R ; TUBBS, Raymond R ; GASCOYNE, Randy ; CONNORS, Joseph M ; WEISENBURGER, Dennis D ; GREINER, Timothy C ; CHAN, Wing-Chung ; CLOT, Guillem ; LOPEZ-GUILLERMO, Armando ; ROSENWALD, Andreas ; OTT, German ; CAMPO, Elías ; JARES, Pedro ; NAVARRO, Alba ; BEA, Sílvia ; PINYOL, Magda ; MARTIN-SUBERO, José I ; KLAPPER, Wolfram ; STAUDT, Louis M ; JAFFE, Elaine S
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	International journal of cancer (Print), Jg. 133 (2013), Heft 12, S. 2852-2863
Veröffentlichung:	Hoboken, NJ: Wiley-Blackwell, 2013
Medientyp:	academicJournal
Umfang:	print, 51 ref
ISSN:	0020-7136 (print)
Schlagwort:	Medical oncology Cancérologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Tumeurs Tumors Hemopathies Hematologic and hematopoietic diseases Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Cancer Cáncer Génétique Genetics Genética Hémopathie maligne Malignant hemopathy Hemopatía maligna Lymphome non hodgkinien Non Hodgkin lymphoma Linfoma no Hodgkin Syndrome lymphoprolifératif Lymphoproliferative syndrome Linfoproliferativo síndrome Cancerology Cancerología Carcinogenèse Carcinogenesis Carcinogénesis Génome Genome Genoma Haute malignité High malignancy Alta malignidad Homme Human Hombre Lymphocyte B B-Lymphocyte Linfocito B Lymphome centrocytique Mantle cell lymphoma Linfoma centrocítico Méthylation Methylation Metilación Pathogénie Pathogenesis Patogenia Séquence nucléotide Nucleotide sequence Secuencia nucleótido Séquence riche GC GC rich sequence Secuencia rica GC Hémopathie lymphoïde B B cell neoplasm genome-wide hypermethylation hypomethylation mantle cell lymphoma pathogenesis
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Genomics Unit, Institut d'lnvestigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain ; Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institut d'lnvestigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain ; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, United States ; Oregon Health and Science University, Portland, OR, United States ; Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway ; Department of Molecular and Anatomic Pathology, Pathology and Laboratory Medicine Institute, Cleveland, OH, United States ; British Columbia Cancer Agency, Vancouver, BC, Canada ; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States ; Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain ; Institute of Pathology, University of Würzburg, Würzburg, Germany ; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany ; Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain ; Hematopathology Section and Lymph Node Registry, Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany ; Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States ; Hematopathology department, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Blood diseases ; Tumours

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features