Mulberry 1-Deoxynojirimycin Pleiotropically Inhibits Glucose-Stimulated Vascular Smooth Muscle Cell Migration by Activation of AMPK/RhoB and Down-regulation of FAK

CHAN, Kuei-Chuan ; LIN, Ming-Cheng ; et al.

In: Journal of agricultural and food chemistry (Print), Jg. 61 (2013), Heft 41, S. 9867-9875

academicJournal - print, 40 ref

Mulberry 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase, has been reported to help prevent diabetes mellitus and suppress lipid accumulation. The aim of this study was to determine whether mulberry DNJ has pleiotropic effects on the development of atherosclerosis. The mechanisms by which mulberry DNJ might inhibit migration of A7r5 vascular smooth muscle cells (VSMCs) under hyperglycemic conditions mimicking diabetes were investigated. The antimigratory effects of DNJ on VSMCs were assessed by Western blot analysis of migration-related proteins and by electric cell-substrate impedance sensing (ECIS) and visualization of F-actin cytoskeleton. Two pathways of DNJ-mediated inhibition of VSMC migration were identified. The first involved AMPK activation to inhibit fatty acid synthase (FASN) and Akt activity and then RhoB activation to inhibit nuclear factor-κB (NF-κB) and matrix metalloproteinase-2 (MMP) activity. The second involved inhibition of focal adhesion kinase (FAK), Ras, and RhoA activity leading to inhibition of F-actin activity.

Titel:	Mulberry 1-Deoxynojirimycin Pleiotropically Inhibits Glucose-Stimulated Vascular Smooth Muscle Cell Migration by Activation of AMPK/RhoB and Down-regulation of FAK
Autor/in / Beteiligte Person:	CHAN, Kuei-Chuan ; LIN, Ming-Cheng ; HUANG, Chien-Ning ; CHANG, Wen-Chun ; WANG, Chau-Jong
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Journal of agricultural and food chemistry (Print), Jg. 61 (2013), Heft 41, S. 9867-9875
Veröffentlichung:	Washington, DC: American Chemical Society, 2013
Medientyp:	academicJournal
Umfang:	print, 40 ref
ISSN:	0021-8561 (print)
Schlagwort:	Agronomy, agriculture, phytopathology Agronomie, agriculture, phytopathologie Food science technology Sciences technologies alimentaires Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Enzyme Enzima Transferases Activation Activación Athérosclérose Atherosclerosis Ateroesclerosis Glucose Glucosa Inhibition Inhibición Migration Migración Muscle lisse Smooth muscle Músculo liso Non-specific serine/threonine protein kinase Régulation Regulation(control) Regulación cAMP-dependent protein kinase AMP activated protein kinase DNJ VSMC atherosclerosis migration
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Internal Medicine, Chung-Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Road, Taichung 402, Tawain, Province of China ; School of Medicine, Institute of Medicine, Chung-Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung 402, Tawain, Province of China ; Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung 402, Tawain, Province of China ; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Road, Taichung 402, Tawain, Province of China Rights: Copyright 2014 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Generalities in biological sciences

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