Vitamin D2 from UVB light exposed mushrooms modulates immune response to LPS in rats
In: Molecular nutrition & food research (Print), Jg. 58 (2014), Heft 2, S. 318-328
Online
academicJournal
- print, 62 ref
Zugriff:
Scope: Poor vitamin D (vitD) status is linked to increased risk of infectious diseases, thus there is need for vitD-rich foods. UVB-exposed mushrooms synthesize vitD2 but knowledge of bioavailability and function in immune response is lacking. Methods and results: One hundred rats were fed one of five diets—control, 20 IU vitD3/day; no vitD3/day; 5% unexposed mushroom, 2.4 IU vitD2/day; 2.5% UVB mushroom, 300 IU vitD2/day; and 5% UVB mushroom, 600 IU vitD2/day—for 10 wk and challenged with either saline or the endotoxin LPS. Blood and tissues were collected at 3 h postchallenge. Plasma 25-hydroxyvitamin D (250HD) levels from UVB-exposed mushroom fed rats were significantly elevated and associated with higher natural killer cell activity and reduced plasma inflammatory response to LPS compared to control diet fed rats. Microarray evaluation of rat spleens for changes in inflammatory gene expression showed significant upregulation of proinflammatory genes after LPS compared to saline controls in all groups. However, compared to control rats, upregulation of the proinflammatory genes was markedly reduced in the groups fed vitD2-enriched mushrooms. Conclusion: Rats fed UVB-exposed mushrooms had significantly higher plasma total 250HD levels that were associated with increased innate immune response and anti-inlfammatory effects.
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Vitamin D2 from UVB light exposed mushrooms modulates immune response to LPS in rats
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Autor/in / Beteiligte Person: | BABU, Uma S ; BALAN, Kannan V ; GARTHOFF, Larry H ; CALVO, Mona S |
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Zeitschrift: | Molecular nutrition & food research (Print), Jg. 58 (2014), Heft 2, S. 318-328 |
Veröffentlichung: | Weinheim: Wiley, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 62 ref |
ISSN: | 1613-4125 (print) |
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