Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes

XIAO, H. W ; LUO, Y ; et al.

In: Bone marrow transplantation (Basingstoke), Jg. 49 (2014), Heft 2, S. 241-247

Online academicJournal - print, 46 ref

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Owing to ethnicity of the population, those best confirmed polymorphisms in the TLR (toll-like receptor)4 and NOD2 genes with significantly prognostic impact on allogeneic hematopoietic SCT (allo-HSCT) seem to be more applicable to Europeans and are nonpolymorphic in the Asian population. The influence of innate immunity gene polymorphisms on the outcomes of allo-HSCT in those populations has been questioned. We evaluated the influence of 10 candidate single nucleotide polymorphisms (SNPs) in the TLR1, TLR2, TLR3, TLR8 and TLR9 genes on the outcomes of allo-HSCT in a Chinese population including 138 pairs of patients and unrelated donors and a second cohort of 102 pairs of patients and HLA-identical sibling donors. We found that two tagSNPs in the TLR9 gene in the donor side, + 1174 A/G (rs352139) and + 1635 C/T (rs352140), influenced the risk of acute GVHD (aGVHD) and CMV reactivation. Furthermore, the presence of the susceptible haplotype (A-C) in donor may be an informative predicator of worse OS at 5 years compared with those with the G-C and G-T haplotypes (58% vs 82.9%, P = 0.024). Our data suggested an unrecognized association between donor TLR9 tagSNPs and the risk of HSCT-related complications in a population without polymorphisms in the TLR4 and NOD2 genes.

Titel:	Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes
Autor/in / Beteiligte Person:	XIAO, H. W ; LUO, Y ; CAI, Z ; LIN, M. F ; HUANG, H ; LAI, X. Y ; SHI, J. M ; TAN, Y. M ; HE, J. S ; XIE, W. Z ; ZHENG, W. Y ; YE, X. J ; YU, X. H
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Bone marrow transplantation (Basingstoke), Jg. 49 (2014), Heft 2, S. 241-247
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2014
Medientyp:	academicJournal
Umfang:	print, 46 ref
ISSN:	0268-3369 (print)
Schlagwort:	Medical oncology Cancérologie Graft, transplantation Greffe, transplantation Hematology Hématologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Anesthesie. Reanimation. Transfusion. Therapie cellulaire et therapie genique Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Transfusions. Complications. Accidents transfusionnels. Thérapie cellulaire et thérapie génique Transfusions. Complications. Transfusion reactions. Cell and gene therapy Greffes de moelle osseuse, cellules souches. Réaction greffon contre l'hôte Bone marrow, stem cells transplantation. Graft versus host reaction Betaherpesvirinae Herpesviridae Immunopathologie Immunopathology Inmunopatología Virus Cellule hématopoïétique Hematopoietic cell Célula hematopoyética Cellule souche Stem cell Célula primitiva Cytomegalovirus Donneur Donor Donador Génotype Genotype Genotipo Génétique Genetics Genética Hematología Maladie du greffon contre l'hôte Graft versus host disease Enfermedad injerto huesped Polymorphisme Polymorphism Polimorfismo Réactivation Reactivation Reactivación Récepteur TLR4 Toll like receptor 4 Receptor TLR4 Récepteur TLR9 Toll like receptor 9 Receptor TLR9 Variabilité génétique Genetic variability Variabilidad genética Greffe de cellules souches hématopoïétiques Hematopoietic stem cell transplantation Injerto de célula primitiva hematopoyética Gène CARD15 CARD15 gene CMV GVHD TLR9 hematopoietic SCT polymorphism
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China ; Department of Haematology, Guangzhou Liuhuaqiao Hospital, Guangzhou, Guangdong, China Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy

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