ETAZOLATE ABROGATES THE LIPOPOLYSACCHARIDE (LPS)-INDUCED DOWNREGULATION OF THE cAMP/pCREB/BDNF SIGNALING, NEUROINFLAMMATORY RESPONSE AND DEPRESSIVE-LIKE BEHAVIOR IN MICE
In: Neuroscience, Jg. 263 (2014), S. 1-14
academicJournal
- print, 2 p.1/4
Zugriff:
Increasing evidence has indicated that immune challenge by bacterial lipopolysaccharide (LPS) induces depressive-like behavior, neuroinflammatory response and upregulates phosphodiesterase-4 (PDE4), an enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP). However, whether the potential PDE4 inhibitor etazolate prevents the LPS-induced depressive-like behavior remains unclear. Here using a model of depression induced by the repeated administration of LPS during 16 days, and then investigated the influence of LPS on the expression of PDE4, interleukin-lp (IL-1β) and antidepressant action of etazolate in mice through forced swimming, novelty suppressed feeding, sucrose preference and open-field tests. Our results showed that etazolate pretreatment facilitated the recovery from weight loss and prevented the depressive-like behavior induced by repeated LPS administration. Moreover, the antidepressant action of etazolate was paralleled by significantly reducing the expression levels of PDE4A, PDE4B, PDE4D and IL-1β and up-regulating the cAMP/phosphorylated cAMP response-element binding protein (pCREB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus and prefrontal cortex of mice. These results indicate that the effects of etazolate on the depressive-like behavior induced by repeated LPS treatment may partially depend on the inhibition of PDE4 subtypes, the activation of the cAMP/pCREB/BDNF signaling and the antiinflammatory responses in the hippocampus and prefrontal cortex.
Titel: |
ETAZOLATE ABROGATES THE LIPOPOLYSACCHARIDE (LPS)-INDUCED DOWNREGULATION OF THE cAMP/pCREB/BDNF SIGNALING, NEUROINFLAMMATORY RESPONSE AND DEPRESSIVE-LIKE BEHAVIOR IN MICE
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Autor/in / Beteiligte Person: | GUO, J ; LIN, P ; ZHAO, X ; ZHANG, J ; WEI, X ; WANG, Q ; WANG, C |
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Zeitschrift: | Neuroscience, Jg. 263 (2014), S. 1-14 |
Veröffentlichung: | Amsterdam: Elsevier, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 2 p.1/4 |
ISSN: | 0306-4522 (print) |
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