Investigation of Cadmium-Induced Genotoxicity and Oxidative Stress Response in Indian Major Carp, Labeo rohita

DABAS, Anurag ; NAGPURE, N. S ; et al.

In: Human and ecological risk assessment, Jg. 20 (2014), Heft 1-2, S. 510-526

academicJournal - print, 3 p.1/4

We investigated genotoxicity and oxidative stress in the gills of Labeo rohita exposed to 33.6, 67.1, and 100.6 mg L-1 of cadmium chloride at 96 h. Genotoxicity was assessed using single cell gel electrophoresis whereas oxidative stress was monitored through lipid peroxidation induction and antioxidant response parameters, namely reduced glutathione (GSH), glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, and catalase (CAT) activities. Significant (p < .05) effect of both concentration and time of exposure was observed on the extent of DNA damage in treated fish. Similarly, malondialdehyde content, level of GSH, and activities of antioxidant enzymes were significantly elevated in treated groups, except CAT. The increased DNA damage and lipid peroxidation (LPO) content along with fluctuation in antioxidant defense system in fish indicated the interaction of cadmium (Cd) with DNA repair processes and production of reactive oxygen species. Thus, Cd is liable for induction of LPO, alteration of antioxidant defenses, and DNA damage in gills of L. rohita.

Titel:	Investigation of Cadmium-Induced Genotoxicity and Oxidative Stress Response in Indian Major Carp, Labeo rohita
Autor/in / Beteiligte Person:	DABAS, Anurag ; NAGPURE, N. S ; MISHRA, R. M ; KUSHWAHA, Basdeo ; KUMAR, Ravindra ; KUMAR, Pavan
Link:	View record from PASCAL Archive
Zeitschrift:	Human and ecological risk assessment, Jg. 20 (2014), Heft 1-2, S. 510-526
Veröffentlichung:	Philadelphia, PA: Taylor & Francis, 2014
Medientyp:	academicJournal
Umfang:	print, 3 p.1/4
ISSN:	1080-7039 (print)
Schlagwort:	Ecotoxicology Ecotoxicologie Ecology Ecologie Environment Environnement Hygiene and public health, epidemiology, occupational medicine Hygiène et santé publique, épidémiologie, médecine du travail Pollution Security, safety Sécurité (multidisciplinaire, général) Toxicology Toxicologie Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Ecologie animale, vegetale et microbienne Animal, plant and microbial ecology Ecologie appliquée Applied ecology Ecotoxicologie, effets biologiques de la pollution Ecotoxicology, biological effects of pollution Action de la pollution et effets secondaires des pesticides sur les vertébrés Effects of pollution and side effects of pesticides on vertebrates Agnatha. Pisces Métal lourd Heavy metal Metal pesado Métal transition Transition metal Metal transición Pisces Toxicité Toxicity Toxicidad Vertebrata Antioxydant Antioxidant Antioxidante Cadmium Cadmio Enzyme Enzima Génotoxicité Genotoxicity Genotoxicidad Labeo rohita Stress oxydatif Oxidative stress Estrés oxidativo antioxidant enzymes cadmium genotoxicity oxidative stress
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Molecular Biology and Biotechnology Division, National Bureau of Fish Genetic Resources, Lucknow, India ; Department of Environmental Biology, Awadhesh Pratap Singh University, Rewa, Madhya Pradesh, India Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Animal, vegetal and microbial ecology

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