Post-β-Lactamase-Inhibitor Effect of Tazobactam in Combination with Ceftolozane on Extended-Spectrum-β-Lactamase-Producing Strains
In: Antimicrobial agents and chemotherapy, Jg. 58 (2014), Heft 4, S. 2434-2437
Online
academicJournal
- print, 17 ref
Zugriff:
The post-β-lactamase-inhibitor effect (PBLIE) of tazobactam combined with ceftolozane was evaluated by time-kill assays on two clinical Escherichia coli strains producing CTX-M-15 with or without TEM-1. The organisms were exposed (2 h) to 4 μg/ ml/4 μg/ml of ceftolozane-tazobactam (4× MIC), 4 μg/ml of ceftolozane, and medium containing no drug, washed, and resuspended in medium alone or medium containing ceftolozane-tazobactam or ceftolozane. The PBLIE was determined as 1.3 to 2.1 h, and a postantibiotic effect was measured as 0.8 to 0.9 h.
Titel: |
Post-β-Lactamase-Inhibitor Effect of Tazobactam in Combination with Ceftolozane on Extended-Spectrum-β-Lactamase-Producing Strains
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Autor/in / Beteiligte Person: | SADER, Helio S ; RHOMBERG, Paul R ; JONES, Ronald N |
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Zeitschrift: | Antimicrobial agents and chemotherapy, Jg. 58 (2014), Heft 4, S. 2434-2437 |
Veröffentlichung: | Washington, DC: American Society for Microbiology, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 17 ref |
ISSN: | 0066-4804 (print) |
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