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Cytomegalovirus (CMV) infection remains a major source of morbidity and mortality in solid organ transplant recipients. Killer immunoglobulin-like receptors (KIR) are genetically polymorphic natural killer (NK) cell receptors important in antiviral responses. A retrospective, single-center cohort study was performed to study the interaction of KIR genotype and primary control of CMV infection after transplantation. Time to first CMV viremia was determined for a cohort of 531 CMV serology donor positive/recipient negative solid organ transplant recipients. Of the KIR genes, KIR2DL3 and KIR2DS2 were most strongly associated with time to CMV viremia in random survival forest analysis. As KIR2DL3 and KIR2DS2 both interact with HLA-C1, these interactions were evaluated. Seventy-six recipients were found to be positive for both KIR2DL3 and KIR2DS2 and expressed only HLA-C1 antigens in both recipient and donor. These patients had a substantially reduced hazard of CMV viremia in the first year after solid organ transplantation (hazard ratio 0.44, 95% CI 0.27―0.72, p = 0.0012). In KIR2DL3+/ KIR2DS2+/HLA-C1/1 recipients who received an organ from a non-C1/1 donor, this protective effect was not observed. These results improve our understanding of human NK cell function in primary CMV infection after transplant.

Titel:	KIR and HLA Interactions Are Associated With Control of Primary CMV Infection in Solid Organ Transplant Recipients
Autor/in / Beteiligte Person:	VAN DUIN, D ; AVERY, R. K ; ASKAR, M ; HEMACHANDRA, S ; YEN-LIEBERMAN, B ; ZHANG, A ; JAIN, A ; BUTLER, R. S ; BARNARD, J ; SCHOLD, J. D ; FUNG, J
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	American journal of transplantation (Print), Jg. 14 (2014), Heft 1, S. 156-162
Veröffentlichung:	Hoboken, NJ: Wiley, 2014
Medientyp:	academicJournal
Umfang:	print, 22 ref
ISSN:	1600-6135 (print)
Schlagwort:	Graft, transplantation Greffe, transplantation Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pathologie infectieuse Infectious diseases Viroses Viral diseases Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Betaherpesvirinae Chirurgie Surgery Cirugía Greffe Graft Injerto Herpesviridae Infection Infección Virus Antigène histocompatibilité classe I Class I histocompatibility antigen Antígeno histocompatibilidad clase I Association Asociación Contrôle Check Control Cytomegalovirus humain Human cytomegalovirus Forêt Forests Bosque Génétique Genetics Genética Homme Human Hombre Homotransplantation Homotrasplante Immunologie Immunology Inmunología Infection opportuniste Opportunistic infection Infección oportunista Interaction Interacción Primoinfection Primary infection Primoinfección Pronostic Prognosis Pronóstico Surveillance Vigilancia Survie Survival Sobrevivencia Système HLA HLA-System Sistema HLA Système histocompatibilité majeur Major histocompatibility system Sistema histocompatibilidad mayor Traitement Treatment Tratamiento Virose Viral disease Virosis Organe solide Solid organ Récepteur KIR Killer immunoglobulin like receptor Cytomegalovirus genetics human leukocyte antigen immunology infectious disease killer immunoglobulin-like receptor random survival forest solid organ transplantation transplantation
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States ; Transplantation Center, Cleveland Clinic, Cleveland, OH, United States ; Division of Infectious Disease (Transplant/Oncology), Johns Hopkins University School of Medicine, Baltimore, MD, United States ; Allogen Laboratories, Cleveland Clinic, Cleveland, OH, United States ; Parkview Regional Medical Center, Fort Wayne, IN, United States ; Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, United States ; Explorys, Inc., Cleveland, OH, United States ; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States ; Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, United States Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Infectious pathology ; Surgery (generalities). Transplants, organs and tissues grafting. Graft pathologies

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KIR and HLA Interactions Are Associated With Control of Primary CMV Infection in Solid Organ Transplant Recipients