Heart Rate―Corrected QT Interval Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Individuals With Type 2 Diabetes: The Diabetes Heart Study
In: Diabetes care, Jg. 37 (2014), Heft 5, S. 1454-1461
Online
academicJournal
- print, 41 ref
Zugriff:
OBJECTIVE Heart rate―corrected QT (QTc) interval is associated with mortality in the general population, but this association is less clear in individuals with type 2 diabetes. We assessed the association of QTc interval with all-cause and cardiovascular disease (CVD) mortality in the Diabetes Heart Study. RESEARCH DESIGN AND METHODS We studied 1,020 participants with type 2 diabetes (83% European Americans; 55% women; mean age 61.4 years) who were free of atrial fibrillation, major ventricular conduction defects, and antiarrhythmic therapy at baseline. QT duration was automatically calculated from a standard 12-lead electrocardiogram (ECG). Following American Heart Association/American College of Cardiology Foundation recommendations, a linear scale was used to correct the QT for heart rate. Using Cox regression, risk was estimated per 1-SD increase in QTc interval as well as prolonged QTc interval (>450 ms) vs. normal QTc interval for mortality. RESULTS At baseline, the mean (SD) QTc duration was 414.9 ms (18.1), and 3.0% of participants had prolonged QTc. After a median follow-up time of 8.5 years (maximum follow-up time 13.9 years), 204 participants were deceased. In adjusted multivariate models, a 1-SD increase in QTc interval was associated with an 18% higher risk for all-cause mortality (hazard ratio 1.18 [95% CI 1.03―1.36]) and 29% increased risk for CVD mortality (1.29 [1.05―1.59]). Similar results were obtained when QTc interval was used as a categorical variable (prolonged vs. normal) (all-cause mortality 1.73 [0.95―3.15]; CVD mortality 2.86 [1.35―6.08]). CONCLUSIONS Heart rate QTc interval is an independent predictor of all-cause and CVD mortality in this population with type 2 diabetes, suggesting that additional prognostic information may be available from this simple ECG measure.
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Heart Rate―Corrected QT Interval Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Individuals With Type 2 Diabetes: The Diabetes Heart Study
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Autor/in / Beteiligte Person: | COX, Amanda J ; AZEEM, Amir ; YEBOAH, Joseph ; SOLIMAN, Elsayed Z ; AGGARWAL, Shivani R ; BERTONI, Alain G ; JEFFREY CARR, J ; FREEDMAN, Barry I ; HERRINGTON, David M ; BOWDEN, Donald W |
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Zeitschrift: | Diabetes care, Jg. 37 (2014), Heft 5, S. 1454-1461 |
Veröffentlichung: | Alexandria, VA: American Diabetes Association, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 41 ref |
ISSN: | 0149-5992 (print) |
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