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Background: Aberrant CXC chemokine receptor 4 (CXCR4) expressions in malignant tissues have been reported; however, its role in kidney cancer prognosis remains unknown. The aim of this study was to determine the prognostic value of CXCR4 expression in patients with clear-cell renal cell carcinoma (ccRCC). Methods: The study included 225 patients with ccRCC. The cohort was split into a training set (n = 125) and a validation set (n=100). CXC chemokine receptor 4 expression was analysed by immunohistochemical staining and its correlations with clinicopathologic features and prognosis were evaluated. Results: CXCR4-staining intensity increased gradually accompanied with disease progression from TNM stages I to IV in 225 patients with ccRCC. Moreover, high CXCR4 expression indicated reduced overall survival (OS) in the training (P<0.001) and validation (P<0.001) sets, especially for patients with early-stage (TNM stage I + II) diseases. Furthermore, CXCR4 expression was identified as an independent prognostic factor for OS, and combining TNM stage with CXCR4 expression showed a better prognostic value for OS in both sets. Conclusions: High CXCR4 expression, an independent adverse prognostic factor, could be combined with TNM stage to generate a predictive nomogram for clinical outcome in patients with ccRCC.

Titel:	High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinoma
Autor/in / Beteiligte Person:	AN, H ; XU, L ; ZHU, Y ; LV, T ; LIU, W ; LIU, Y ; LIU, H ; CHEN, L ; XU, J ; LIN, Z
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	British journal of cancer, Jg. 110 (2014), Heft 9, S. 2261-2268
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2014
Medientyp:	academicJournal
Umfang:	print, 1 p.1/4
ISSN:	0007-0920 (print)
Schlagwort:	Medical oncology Cancérologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Tumeurs Tumors Tumeurs multiples. Tumeurs solides. Tumeurs chez l'enfant (généralités) Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrologie. Maladies des voies urinaires Nephrology. Urinary tract diseases Tumeurs de l'appareil urinaire Tumors of the urinary system Reins Kidneys Cancer Cáncer Pathologie de l'appareil urinaire Urinary system disease Aparato urinario patología Pathologie du rein Kidney disease Riñón patología Tumeur maligne Malignant tumor Tumor maligno Cancer rein Kidney cancer Cáncer del riñón Cancerology Cancerología Carcinome cellule claire Clear cell carcinoma Carcinoma célula clara Chimiokine CXC CXC chemokine Quimioquina CXC Homme Human Hombre Hypernéphrome Grawitz tumor Hipernefroma Modèle Models Modelo Mésonéphrome Mesonephroma Mesonefroma Nomogramme Nomogram Nomograma Pronostic Prognosis Pronóstico Récepteur biologique Biological receptor Receptor biológico Récepteur chimiokine CXC CXC chemokine receptor Receptor quimioquina CXC Récepteur chimiokine CXCR4 CXCR4 chemokine receptor Receptor quimioquina CXCR4 Récepteur chimiokine Chemokine receptor Receptor quimioquina Survie Survival Sobrevivencia CXCR4 ccRCC nomogram overall survival prognostic model
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Urology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai 200032, China ; Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China ; Department of Biochemistry and Molecular Biology, Key Laboratory of Glycoconjugate Research, MOH, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China ; Department of Pathology, Children's Hospital, Shanghai Medical College of Fudan University, Shanghai 201102, China Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Nephrology. Urinary tract diseases ; Tumours

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High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinoma