High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinoma
In: British journal of cancer, Jg. 110 (2014), Heft 9, S. 2261-2268
Online
academicJournal
- print, 1 p.1/4
Zugriff:
Background: Aberrant CXC chemokine receptor 4 (CXCR4) expressions in malignant tissues have been reported; however, its role in kidney cancer prognosis remains unknown. The aim of this study was to determine the prognostic value of CXCR4 expression in patients with clear-cell renal cell carcinoma (ccRCC). Methods: The study included 225 patients with ccRCC. The cohort was split into a training set (n = 125) and a validation set (n=100). CXC chemokine receptor 4 expression was analysed by immunohistochemical staining and its correlations with clinicopathologic features and prognosis were evaluated. Results: CXCR4-staining intensity increased gradually accompanied with disease progression from TNM stages I to IV in 225 patients with ccRCC. Moreover, high CXCR4 expression indicated reduced overall survival (OS) in the training (P<0.001) and validation (P<0.001) sets, especially for patients with early-stage (TNM stage I + II) diseases. Furthermore, CXCR4 expression was identified as an independent prognostic factor for OS, and combining TNM stage with CXCR4 expression showed a better prognostic value for OS in both sets. Conclusions: High CXCR4 expression, an independent adverse prognostic factor, could be combined with TNM stage to generate a predictive nomogram for clinical outcome in patients with ccRCC.
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High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinoma
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Autor/in / Beteiligte Person: | AN, H ; XU, L ; ZHU, Y ; LV, T ; LIU, W ; LIU, Y ; LIU, H ; CHEN, L ; XU, J ; LIN, Z |
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Zeitschrift: | British journal of cancer, Jg. 110 (2014), Heft 9, S. 2261-2268 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/4 |
ISSN: | 0007-0920 (print) |
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